Evidence map›Paper›PMID 36922901›Full record

ArticleActa neuropathologica communications2023

Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain.

Pei-Ying Wang, Ting-Yu Kuo, Lee-Hsin Wang, Wen-Hsing Liang, Guey-Shin Wang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pei-Ying Wang *Institute of Biomedical Sciences, Academia Sinica, 128, Section 2, Academia Rd. Nangang, Taipei, 115, Taiwan.
Ting-Yu Kuo *Institute of Biomedical Sciences, Academia Sinica, 128, Section 2, Academia Rd. Nangang, Taipei, 115, Taiwan.
Lee-Hsin WangInstitute of Biomedical Sciences, Academia Sinica, 128, Section 2, Academia Rd. Nangang, Taipei, 115, Taiwan.
Wen-Hsing LiangInstitute of Biomedical Sciences, Academia Sinica, 128, Section 2, Academia Rd. Nangang, Taipei, 115, Taiwan.
Guey-Shin WangInstitute of Biomedical Sciences, Academia Sinica, 128, Section 2, Academia Rd. Nangang, Taipei, 115, Taiwan. gswang@ibms.sinica.edu.tw.ORCID 0000-0003-4485-1811
Institute of Biomedical Sciences, Academia Sinica · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of CTG trinucleotide repeats in the 3' untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene. Mutant DMPK mRNA containing expanded CUG RNA (DMPK-CUG

Indexed as

Myotonic DystrophyAnimalsBrainBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2DNA-Binding ProteinsMiceMyotonin-Protein KinaseRNARNA-Binding ProteinsTrinucleotide Repeat ExpansionBrain-Derived Neurotrophic FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2DNA-Binding ProteinsMbnl1 protein, mouseMyotonin-Protein KinaseRNARNA-Binding ProteinsBDNFDYNLL2MBNL1Myotonic dystrophyRetrograde transport

Identifiers

PMID36922901
PMCPMC10018927
OpenAlexW4327681631

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read40
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.