ArticleTropical diseases, travel medicine and vaccines2023
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia.
Article in Tropical diseases, travel medicine and vaccines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Epidemiological and Evolutionary Dynamics of Dengue Virus in Saudi Arabia: Insights from Three Decades of Molecular and Serological Surveillance.International journal of molecular sciences · 2026Pooled it
- Neglected Tropical Diseases (NTDs) in Saudi Arabia: Systematic Review and Meta-analysis.Journal of epidemiology and global health · 2025Pooled it
- Dengue virus infection in Saudi Arabia from 2003 to 2023: a systematic review and meta-analysis.Pathogens and global healthPooled it
- Molecular and Biochemical Characterization of Insecticide Resistance in Field-CaughtACS omega · 2026Article
- Climate Change and Emerging Arboviral Threats in Saudi Arabia: Epidemiology, Vector Ecology, and One Health Preparedness.Infectious disease reports · 2026Review
- Epidemiological characterisation of dengue fever across Saudi Arabia.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026Article
- Co-infection of SARS-CoV-2 and DENV case report in Jazan Region Southwest Saudi Arabia.BMC infectious diseases · 2026Article
- Article
- Molecular Evidence of Dengue Virus Serotype 2 in Travelers Returning to Israel from the Sinai Peninsula.Emerging infectious diseases · 2025Article
- Current trends and challenges in the management of foot and mouth disease in Saudi Arabia: A review.Open veterinary journal · 2025Review
- Current epidemiological status of mosquito-borne arboviruses in Gulf countries: a systematic review and meta-analysis.Tropical diseases, travel medicine and vaccines · 2025Review
- Hematological parameters in recent and past dengue infections in Jazan Province, Saudi Arabia.Saudi medical journal · 2025Article
- Dengue fever with bilateral thalamic diffusion restriction lesions: a case report.BMC neurology · 2025Article
- Genotypic diversity and molecular characterization of DENV-2 in a Peruvian endemic region from 2016 to 2022: displacement of American/Asian genotype.Frontiers in microbiology · 2025Article
- Multi-epitope peptide vaccines targeting dengue virus serotype 2 created via immunoinformatic analysis.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to investigate the genetic variants of DENV-2 that were circulating during a serious outbreak in Jazan region in 2019.
methodsA total of 482 serum samples collected during 2019 from Jazan region were tested with reverse transcription-polymerase chain reaction (RT-PCR) to detect and classify DENV; positive samples underwent sequencing and bioinformatics analyses.
resultsOut of 294 positive samples, type-specific RT-PCR identified 58.8% as DENV-2 but could not identify 41.2%. Based on sequencing and bioinformatics analyses, the samples tested PCR positive in the first round but PCR negative in the second round were found to be imported genetic variant of DENV-2. The identified DENV-2 imported variant showed similarities to DENV-2 sequences reported in Malaysia, Singapore, Korea and China. The results revealed the imported genetic variant of DENV-2 was circulating in Jazan region that was highly prevalent and it was likely a major factor in this outbreak.
conclusionsThe emergence of imported DENV variants is a serious challenge for the dengue fever surveillance and control programmes in endemic areas. Therefore, further investigations and continuous surveillance of existing and new viral strains in the region are warranted.
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