Evidence map›Paper›PMID 36922769›Full record

ArticleBMC pediatrics2023

Viral load suppression in HIV-infected adolescents in cameroon: towards achieving the UNAIDS 95% viral suppression target.

Armando B D Djiyou, Calixte Ida Penda, Yoann Madec, Grace Dalle Ngondi, Astrid Moukoko, Marie Varloteaux, Laure-Amélie de Monteynard, Cecile Moins, Carole Else Eboumbou Moukoko, Avelin F Aghokeng

Registry-linked trialOpen access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04593979 (Virological Failure and HIV Drug Resistance Among Adolescents Receiving Antiretroviral Treatment in Cameroon), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04593979 unknown statusnot on this map

Virological Failure and HIV Drug Resistance Among Adolescents Receiving Antiretroviral Treatment in Cameroon

TypeobservationalSponsorANRS, Emerging Infectious DiseasesRan2021 to 2022Enrolled289ConditionsHIV-1-infection
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Armando B D DjiyouDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Calixte Ida PendaDepartment of Clinical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Yoann MadecEpidemiology of emerging diseases, Institut Pasteur, Université de Paris, F-75015, Paris, France.
Grace Dalle NgondiHôpital Laquintinie, Douala, Cameroun.
Astrid MoukokoHôpital Laquintinie, Douala, Cameroun.
Marie VarloteauxAgence Nationale de Recherches sur le Sida et les hépatites virales (ANRS | Maladies infectieuses émergentes), Paris, France.
Laure-Amélie de MonteynardAgence Nationale de Recherches sur le Sida et les hépatites virales (ANRS | Maladies infectieuses émergentes), Paris, France.
Cecile MoinsAgence Nationale de Recherches sur le Sida et les hépatites virales (ANRS | Maladies infectieuses émergentes), Paris, France.
Carole Else Eboumbou MoukokoDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Avelin F AghokengUMR MIVEGEC, IRD, Université de Montpellier, CNRS, IRD, 911, avenue Agropolis, PO. Box 64501, 34394, Montpellier, Montpellier Cedex 5, France. avelin.aghokeng@ird.fr.
University of Douala · CMAgence Nationale de Recherches sur le Sida et les Hépatites Virales · FRCentre National de la Recherche Scientifique · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAchieving the UNAIDS 95% sustained viral suppression (VS) rate requires considerable global efforts, particularly among adolescents living with HIV (ALHIV) who are often associated with high rates of virological failure (VF). In this study, we prospectively assessed the rate of VS, and the factors associated with VF in a cohort of adolescents followed up according to the WHO guidelines in Cameroon.

methodsA cross-sectional study was carried out in 2021 among adolescents (aged 10-19 years) receiving ART in the national program in Cameroon. Socio-demographic and clinical data were collected using patients' medical files and a brief interview with the participant and/or his guardian. Thereafter, a first viral load test (VL1) was performed using the ABBOTT Platform. For adolescents with VL1 > 1000 copies/ml, adherence-enhancing interventions were routinely performed each month for 3 consecutive months, after which a second viral load (VL2) was measured. Adolescents with VL2 > 1000 copies/ml were considered in VF.

resultsOverall, 280 adolescents were enrolled, of whom 89.3% (250/280) acquired HIV infection via mother-to-child transmission. The median age was 16.0 (IQR: 13.0-18.0) years and the median duration on ART was 9.8 (IQR: 5.1-12.8) years. Females and males were almost equally represented, as 52.1% (146/280) were female, while 47.9% (134/280) were males (p = 0.47). The VS rate was 88.2% (CI: 83.8-91.7%) overall; 89.0% (CI: 82.0-93.1%) and 88.7% (CI: 81.2-93.0%) in females and males, respectively. Being on second or third-line ART, self-declared suboptimal adherence, and a history of past VF were independently associated with VF.

conclusionThe high rate of VS we report in this study is welcome in the era of the 95/95/95 UNAIDS goals, and indicates that improving treatment outcomes in this specific and fragile population that represent adolescents in Sub-Saharan Africa is achievable.

trial registration20/10/2020 NCT04593979 ( https://clinicaltrials.gov/ct2/show/NCT04593979 ).

Indexed as

Anti-HIV AgentsHIV InfectionsAdolescentCameroonCross-Sectional StudiesFemaleHumansInfectious Disease Transmission, VerticalMaleViral LoadAnti-HIV AgentsAdolescentsAntiretroviral treatmentCameroonHIV-AIDSViral load suppression

Identifiers

PMID36922769
PMCPMC10015512
OpenAlexW4324359557

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read63
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.