Evidence map›Paper›PMID 36922640›Full record

ArticleScientific reports2023

DNA methyltransferase inhibition induces dynamic gene expression changes in lung CD4

Sylvia N Michki, Roland Ndeh, Kathryn A Helmin, Benjamin D Singer, Sharon A McGrath-Morrow

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Sylvia N MichkiChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA, 19104, USA. michkin@chop.edu.
Roland NdehEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, 21287, USA.
Kathryn A HelminDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine Chicago, Chicago, IL, 60611, USA.
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine Chicago, Chicago, IL, 60611, USA.
Sharon A McGrath-MorrowChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA, 19104, USA.
Children's Hospital of Philadelphia · USNorthwestern University · USJohns Hopkins University · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Trevor M Penning · 2006 to 2026
$35.3M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Resolution of Diffuse Inflammatory Lung Injury in Neonatal MiceR01HL114800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MCGRATH-MORROW, SHARON ANN · 2013 to 2021
$3.3M
Epigenetic modifiers of regulatory T cell function following viral pneumoniaR01HL153122 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2021 to 2021
$63k
NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL114800NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NIA NIH HHS P01 AG049665NIEHS NIH HHS P30 ES013508NIH HHS R01 HL114800NIH HHS R01 HL149883
6 · The paper itself

Abstract

Bacterial pulmonary infections are a major cause of morbidity and mortality in neonates, with less severity in older children. Previous studies demonstrated that the DNA of CD4

Indexed as

Escherichia coli InfectionsPneumonia, BacterialAnimalsAnimals, NewbornCD4-Positive T-LymphocytesDNA MethylationDNA Modification MethylasesEscherichia coliGene ExpressionLungMiceT-LymphocytesDNA Modification Methylases

Identifiers

PMID36922640
PMCPMC10017701
OpenAlexW4327681933

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read20
table measurements read2
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.