Evidence map›Paper›PMID 36922599›Full record

ArticleNature2023

A swapped genetic code prevents viral infections and gene transfer.

Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V Owen, Eleanor A Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A Marchand, Maximilien Baas-Thomas and 6 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 86 citations in OpenAlex.

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  11. Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Akos NyergesDepartment of Genetics, Harvard Medical School, Boston, MA, USA. akos_nyerges@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1581-490X
Svenja VinkeDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Regan FlynnDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Siân V OwenDepartment of Biomedical Informatics and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5330-3177
Eleanor A RandDepartment of Biomedical Informatics and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.
Bogdan BudnikWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.
Eric KeenDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St Louis, MO, USA.
Kamesh NarasimhanDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5065-1085
Jorge A MarchandDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Maximilien Baas-ThomasDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9821-9585
Min LiuGenScript USA Inc., Piscataway, NJ, USA.
Kangming ChenGenScript USA Inc., Piscataway, NJ, USA.
Anush Chiappino-PepeDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3993-907X
Fangxiang HuGenScript USA Inc., Piscataway, NJ, USA.
Michael BaymDepartment of Biomedical Informatics and Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1303-5598
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA. gchurch@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0003-3535-2076
Harvard University · USAllscripts (United States) · USWashington University in St. Louis · US

Funding

Evolutionary Tradeoffs in Antibiotic ResistanceR35GM133700 · NIGMS · HARVARD MEDICAL SCHOOL · PI BAYM, MICHAEL · 2019 to 2023
$2.4M
NIGMS NIH HHS R35 GM133700
6 · The paper itself

Abstract

Engineering the genetic code of an organism has been proposed to provide a firewall from natural ecosystems by preventing viral infections and gene transfer

Indexed as

Amino AcidsEscherichia coliGenetic CodeGene Transfer, HorizontalHost Microbial InteractionsProtein BiosynthesisVirus DiseasesCodonEcosystemGenome, BacterialLeucineOrganisms, Genetically ModifiedRNA, TransferSerineViral ProteinsAmino AcidsCodonLeucineRNA, TransferSerineViral Proteins

Identifiers

PMID36922599
PMCPMC10151025
OpenAlexW4324344178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.