Evidence map›Paper›PMID 36922591›Full record

ArticleNature2023

Structural basis of odorant recognition by a human odorant receptor.

Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
43.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 212 citations in OpenAlex.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Christian B Billesbølle *Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8084-1552
Claire A de March *Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6461-5547
Wijnand J C van der Velden *Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID http://orcid.org/0000-0003-0785-3762
Ning MaDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Jeevan TewariDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6786-3917
Claudia Llinas Del TorrentDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Linus LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8302-7860
Bryan FaustDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Nagarajan VaidehiDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA. NVaidehi@coh.org.ORCID http://orcid.org/0000-0001-8100-8132
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. hiroaki.matsunami@duke.edu.ORCID http://orcid.org/0000-0002-8850-2608
Aashish ManglikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. aashish.manglik@ucsf.edu.ORCID http://orcid.org/0000-0002-7173-3741
University of California, San Francisco · USCity of Hope · USDuke University · USCentre National de la Recherche Scientifique · FRCity Of Hope National Medical Center · USUniversitat Autònoma de Barcelona · ES

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
Enhancing olfactory receptor expression for biochemical studies of odorant-receptor interactionsR01DC020353 · NIDCD · DUKE UNIVERSITY · PI Aashish Manglik, Hiroaki Matsunami · 2022 to 2026
$3.3M
Acquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0M
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
Understanding of G protein-coupled odorant receptors functionK99DC018333 · NIDCD · DUKE UNIVERSITY · PI DE MARCH, CLAIRE A. · 2020 to 2021
$172k
NIDCD NIH HHS K99 DC018333NIDCD NIH HHS K99DC018333NIDCD NIH HHS R01 DC020353NIDCD NIH HHS R01DC020353NIGMS NIH HHS T32 GM008284NIH HHS S10 OD020054NIH HHS S10OD020054NIH HHS S10 OD021741NIH HHS S10OD021741
6 · The paper itself

Abstract

Our sense of smell enables us to navigate a vast space of chemically diverse odour molecules. This task is accomplished by the combinatorial activation of approximately 400 odorant G protein-coupled receptors encoded in the human genome

Indexed as

Cryoelectron MicroscopyOdorantsPropionatesReceptors, OdorantBinding SitesHumansMolecular Dynamics SimulationMutationNeoplasm ProteinsSmellSubstrate SpecificityNeoplasm ProteinsOR51E2 protein, humanPropionatesReceptors, Odorant

Identifiers

PMID36922591
PMCPMC10580732
OpenAlexW4324344258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.