ArticleNature2023
Spatial mapping of mitochondrial networks and bioenergetics in lung cancer.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
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Who cites it
93 citing papers in PubMed.
- Mitochondrial mechanisms underlying spatial immune phenotypes in non‑small cell lung cancer: Implications for ICI response and cold‑to‑hot tumor conversion (Review).Oncology reports · 2026Review
- Local control of Cre-regulated genetic modeling in vivo using wireless implantable optoelectronics.Science advances · 2026Article
- A computational super-resolution framework for multidimensional fluorescence imaging.Science advances · 2026Article
- How mitochondrial heterogeneity fuels a dynamic organelle ecosystem.Communications biology · 2026Review
- DLST Succinylation-Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intensification versus combination: revisiting the past and envisioning the future of LDHA inhibitors.Cancer chemotherapy and pharmacology · 2026Review
- The RAB32-USP13 axis facilitates TOM40 mitochondrial localization to promote non-small cell lung cancer progression.Cell death and differentiation · 2026Article
- Multifunctional biohybrid nanoplatform interferes electron transport chain amplifying mitochondrial metabolism-mediated anti-tumor therapy.Materials today. Bio · 2026Article
- Opposing roles of DGAT-mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity.The FEBS journal · 2026Article
- Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications.Journal of hematology & oncology · 2026Review
- Illuminating aging with multimodal optical metabolic imaging.Science advances · 2026Review
- Flavonoid compounds from Shenrong Guben Huanshao Pill alleviates senescence-associated mitochondrial dysfunction through NDUFV2 and LDHB mediated metabolic reprogramming.Journal of pharmaceutical analysis · 2026Article
- 3D EM uncovers mitochondrial network remodeling in residual triple negative breast cancer after conventional chemotherapy treatments.iScience · 2026Article
- Tuning the Fire: Context-Dependent Mitochondrial ROS Signaling, Mitohormesis, and Redox-Modulating Interventions.Biomolecules · 2026Review
- Mitochondrial OXPHOS restricts SARS-CoV-2 replication.Science advances · 2026Article
- MTHFR functions as a metabolic checkpoint in NSCLC through SLC25A26-mediated SHMT2 inhibition.Cell death & disease · 2026Article
- Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.The EMBO journal · 2026Article
- Targeting mitocytosis potentiates mitochondria drug delivery for antimetastasis therapy.Science advances · 2026Article
- Single-Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities.Molecular cancer · 2026Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors.
Mingqi HanPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Eric A BushongDepartment of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.
Mayuko SegawaUniversity of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5680-9576
Alexandre TiardDepartment of Computer Science, UCLA, Los Angeles, CA, USA.
Alex WongDepartment of Computer Science, Yale University, New Haven, CT, USA.
Morgan R BradyPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Milica MomcilovicPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Dane M WolfUniversity of Cambridge, Cambridge, UK.
Ralph ZhangPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5855-1428
Anton PetcherskiDepartment of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA.
Matthew MadanyDepartment of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.
Shili XuDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.
Jason T LeeDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2590-2011
Masha V PoyurovskyKadmon Corporation, New York, NY, USA.
Kellen OlszewskiKadmon Corporation, New York, NY, USA.
Travis HollowayDepartment of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4533-4851
Adrian GomezDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8982-4369
Maie St JohnJonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
Steven M DubinettPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3656-8039
Carla M KoehlerDepartment of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.
Orian S ShirihaiDepartment of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8466-3431
Linsey StilesDepartment of Endocrinology, DGSOM UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1514-458X
Aaron LisbergJonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.
Stefano SoattoDepartment of Computer Science, UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2902-6362
Saman SadeghiDepartment of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada.
Mark H EllismanDepartment of Neurosciences, University of California San Diego (UCSD), San Diego, CA, USA.ORCID http://orcid.org/0000-0001-8893-8455
David B ShackelfordPulmonary and Critical Care Medicine, David Geffen School of Medicine (DGSOM), University of California Los Angeles (UCLA), Los Angeles, CA, USA. dshackelford@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-8270-898X
Funding
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MThe Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1MNational Center for Microscopy and Imaging Research: A BRAIN Technology Integration and Dissemination ResourceU24NS120055 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2021 to 2025
$5.4MUCLA Clinical and Translational Science InstituteKL2TR000122 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$4.5M(PQ5) Imaging mitochondrial heterogeneity in LKB1 mutant lung cancerR01CA208642 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David B Shackelford · 2016 to 2026
$3.9MThe National Center for Microscopy and Imaging Research, a Community-wide Scientific ResourceR24GM137200 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2022
$3.0MIn Vivo Imaging of Mitochondria Structure and Function in Therapy Resistant Lung TumorsR01CA267721 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI David B Shackelford · 2022 to 2026
$3.0MIntratumoral Administration of CCL21-gene Modified Dendritic Cell With Intravenous Pembrolizumab for Advanced NSCLCK08CA245249 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LISBERG, AARON ELLIOTT · 2020 to 2024
$1.3MNCATS NIH HHS KL2 TR000122NCATS NIH HHS KL2 TR001882NCATS NIH HHS KL2TR001882NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1TR001881NCI NIH HHS K08 CA245249NCI NIH HHS K08 CA245249-01A1NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA208642NCI NIH HHS R01 CA208642-01NCI NIH HHS R01 CA267721NIGMS NIH HHS R24 GM137200NINDS NIH HHS U24 NS120055
Abstract
Mitochondria are critical to the governance of metabolism and bioenergetics in cancer cells
Indexed as
Carcinoma, Non-Small-Cell LungEnergy MetabolismLung NeoplasmsMitochondriaFatty AcidsGlucoseHumansLipid DropletsMicroscopy, ElectronOxidative PhosphorylationPhenotypePositron-Emission TomographyFatty AcidsGlucose
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Textfull text, public
LicenceCC BY
measurements read89
identifiers read1
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.