ArticleCommunications biology2023
Anterior cingulate and medial prefrontal cortex oscillations underlie learning alterations in trait anxiety in humans.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Comparing Different Montages of Transcranial Direct Current Stimulation in Treating Treatment-Resistant Obsessive Compulsive Disorder: A Randomized, Single-Blind Clinical Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Impact of multilingualism on cardiac autonomic activity, working memory and trait anxiety: a pilot study.Cognitive processing · 2026Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Anhedonia and Anxious Arousal Are Associated With Distinct Expectations About the Statistics of a Volatile Environment.Biological psychiatry global open science · 2026Article
- A causal role of the ventromedial prefrontal cortex in regulating anticipated regret and risk behaviors in trait anxiety.Psychological medicine · 2026Article
- [Effects ofZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Causal Brain Network Alterations Across Disease Stages in Herpes Zoster and Postherpetic Neuralgia.Journal of pain research · 2026Article
- Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry.Nature communications · 2025Article
- Trait anxiety is associated with reduced reward-related replay at rest.Nature communications · 2025Article
- VTA-ACC dopaminergic circuit mediates trait anxiety-related observational learning of social avoidance in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Maternal anxiety shapes prediction error responses in the infant brain.Neurophotonics · 2025Article
- Preparing to act follows Bayesian inference rules.iScience · 2025Article
- Neural correlates of affective forecasting in individuals with high trait anxiety: evidence from resting-state functional connectivity.Brain imaging and behavior · 2025Article
- Frequency-specific changes in prefrontal activity associated with maladaptive belief updating in volatile environments in euthymic bipolar disorder.Translational psychiatry · 2025Article
- Computational Mechanisms of Information-Seeking in Anxiety.Current topics in behavioral neurosciences · 2025Review
- Diminished pain sensitivity mediates the relationship between psychopathic traits and reduced learning from pain.Communications psychology · 2024Article
- Enhanced "learning to learn" through a hierarchical dual-learning system: the case of action video game players.BMC psychology · 2024Article
- Evaluating the Influence of Musical and Monetary Rewards on Decision Making through Computational Modelling.Behavioral sciences (Basel, Switzerland) · 2024Article
- RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain.Computational psychiatry (Cambridge, Mass.) · 2024Review
- Are the Post-COVID-19 Posttraumatic Stress Disorder (PTSD) Symptoms Justified by the Effects of COVID-19 on Brain Structure? A Systematic Review.Journal of personalized medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety has been linked to altered belief formation and uncertainty estimation, impacting learning. Identifying the neural processes underlying these changes is important for understanding brain pathology. Here, we show that oscillatory activity in the medial prefrontal, anterior cingulate and orbitofrontal cortex (mPFC, ACC, OFC) explains anxiety-related learning alterations. In a magnetoencephalography experiment, two groups of human participants pre-screened with high and low trait anxiety (HTA, LTA: 39) performed a probabilistic reward-based learning task. HTA undermined learning through an overestimation of volatility, leading to faster belief updating, more stochastic decisions and pronounced lose-shift tendencies. On a neural level, we observed increased gamma activity in the ACC, dmPFC, and OFC during encoding of precision-weighted prediction errors in HTA, accompanied by suppressed ACC alpha/beta activity. Our findings support the association between altered learning and belief updating in anxiety and changes in gamma and alpha/beta activity in the ACC, dmPFC, and OFC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.