Evidence map›Paper›PMID 36922500›Full record

ArticleSignal transduction and targeted therapy2023

Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine.

Shaofu Qiu, Zhao Chen, Airu Zhu, Qiuhui Zeng, Hongbo Liu, Xiaoqing Liu, Feng Ye, Yingkang Jin, Jie Wu, Chaojie Yang and 14 more

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 5 institutions in 1 country.

Shaofu Qiu *The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Zhao Chen *State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Airu Zhu *State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Qiuhui Zeng *State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Hongbo Liu *The Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Xiaoqing LiuState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Feng YeState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Yingkang JinPediatric Pulmonary Department, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510623, Guangzhou, Guangdong, China.
Jie WuGuangdong Provincial Center for Disease Control and Prevention, 510399, Guangzhou, Guangdong, China.
Chaojie YangThe Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Qi WangThe Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Fangli ChenState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Lan ChenState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Sai TianThe Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Xinying DuThe Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China.
Qingtao HuState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Jinling ChengState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Canjie ChenState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Fang LiState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Jing SunState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Yanqun WangState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Jingxian ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojingxian@gird.cn.
Jincun ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojincun@gird.cn.ORCID 0000-0003-2515-5589
Hongbin SongThe Chinese PLA Center for Disease Control and Prevention, 100071, Beijing, China. hongbinsong@263.net.
First Affiliated Hospital of Guangzhou Medical University · CNShanghaiTech University · CNChinese Center For Disease Control and Prevention · CNGuangdong Provincial Center for Disease Control and Prevention · CNGuangzhou Women and Children Medical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4

Indexed as

COVID-19Antibodies, ViralAsymptomatic InfectionsCOVID-19 VaccinesHumansSARS-CoV-2Ad5-nCoV vaccineAntibodies, ViralCOVID-19 Vaccines

Identifiers

PMID36922500
PMCPMC10015148
OpenAlexW4324366427

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read63
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.