ArticleInfectious diseases and therapy2023
Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000-2012).
Article in Infectious diseases and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Native valve endocarditis due to Staphylococcus kloosii: a brief report.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- The geriatric syndromes in elderly patients with infective endocarditis: impact on in-hospital mortality.Journal of geriatric cardiology : JGC · 2026Article
- Infective Endocarditis in Ireland: A Nationwide Analysis.Journal of clinical medicine · 2026Article
- Infective endocarditis in a university hospital without on-site cardiac surgery: temporal trends over 37 years.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Choice of antimicrobial therapy for infective endocarditis caused by viridans streptococci: an international practice survey.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Clinical Experience of Ceftaroline Fosamil in Gram-Positive Infective Endocarditis: A Multicenter Real-World Observational Study.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Prosthetic Valve Endocarditis-Insights from the NatIonal Danish Endocarditis stUdieS (NIDUS) Registry.Diagnostics (Basel, Switzerland) · 2026Article
- Early outcomes and predictors of mortality in native aortic valve endocarditis: results from a national registry.Open heart · 2026Article
- Methicillin-ResistantMicroorganisms · 2026Review
- From structural heart lesions to host burden: changing epidemiology and outcomes of native valve infective endocarditis, a nationwide study, 2006-2023.Open heart · 2026Article
- Eravacycline-Cefiderocol Combination Therapy for Carbapenem-ResistantInfection and drug resistance · 2026Article
- Multimodality Imaging in Infective Endocarditis: A Clinical Approach to Diagnosis.Medicina (Kaunas, Lithuania) · 2025Review
- Predictors for short-term outcome in patients with left-sided infective endocarditis: insight from Invention - HK registry.Open heart · 2025Article
- [Contemporary management of endocarditis].Herz · 2025Review
- Clinical burden of Clostridioides difficile infection in infective endocarditis: a single-center experience.Internal and emergency medicine · 2025Article
- Sex Differences in Clinical Outcomes and Surgical Interventions for Infective Endocarditis: A Nationwide Registry.Open forum infectious diseases · 2025Article
- Infective endocarditis: it takes a team.European heart journal · 2025Review
- Autologous leaflet reconstruction for aortic valve endocarditis.JTCVS techniques · 2025Article
- [Impact of a dedicated multidisciplinary committee (Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionInfective endocarditis (IE) has undergone important changes in its epidemiology worldwide.
methodsThe study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century.
resultsIE cases from 13 European countries were included. Two periods were considered: 2000-2006 and 2008-2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern-Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 63.7 (49-74) years and 69.4% were males. Native valve IE (NVE), prosthetic valve IE (PVE), and device-related IE were diagnosed in 68.3%, 23.9%, and 7.8% of cases, respectively; 52% underwent surgery and 19.3% died during hospitalization. NVE was more prevalent in NCE, whereas device-related IE was more frequent in SE. Higher age, acute presentation, hemodialysis, cancer, and diabetes mellitus all were more prevalent in the second period. NVE decreased and PVE and device-related IE both increased in the second period. Surgical treatment also increased from 48.7% to 58.4% (p < 0.01). In-hospital and 6-month mortality rates were comparable between regions and significantly decreased in the second period.
conclusionsDespite an increased complexity of IE cases, prognosis improved in recent years with a significant decrease in 6-month mortality. Outcome did not differ according to the European region (SE versus NCE).
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