ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023
The Forces Generated by Agonist Muscles during Isometric Contractions Arise from Motor Unit Synergies.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 86 citations in OpenAlex.
- Common inputs to motor units are modulated by force profile and muscle length.Experimental physiology · 2026Article
- A dataset for bilateral lower limb muscle synergy patterns in unilateral anterior cruciate ligament reconstructed patients.Scientific data · 2026Article
- Structured modulations in high-density EMG patterns from a single muscle enable simultaneous control of natural and extra degrees of freedom.Journal of neuroengineering and rehabilitation · 2026Article
- Voluntary Dissociation of Motor Unit Activity in the Vastii Muscles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Functional changes in spinal circuitry in essential tremor revealed with analysis of intramuscle synergies.Journal of neurophysiology · 2026Article
- Independent neural drives and distinct motor unit discharge characteristics in hamstring muscles during isometric knee flexion.European journal of applied physiology · 2026Article
- Adaptation of motor unit synergies in the synergetic ankle plantarflexors in ambulatory persons with incomplete spinal cord injury.Journal of neuroengineering and rehabilitation · 2026Article
- Leveraging neural drive to assess hand motor function in individuals with chronic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Analysis of motor units with high-density surface electromyography: methodological considerations and physiological significance.European journal of applied physiology · 2026Review
- Lower limb muscle synergies during deceleration at different change of direction angles.Scientific reports · 2025Article
- Unilateral Resistance Training Strategies for Boosting Rehabilitation: An Expert Survey.Journal of functional morphology and kinesiology · 2025Article
- A single low-dimensional neural component of spinal motor neuron activity explains force generation across repetitive isometric tasks.iScience · 2025Article
- Networks of intermuscular coordination distinguish male and female responses to exercise.Scientific reports · 2025Article
- The neuromechanical delay of the quadriceps shortens with increasing contraction intensity.Scientific reports · 2025Article
- Non-homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity.The Journal of physiology · 2025Article
- Effects of spinal transection and locomotor speed on muscle synergies of the cat hindlimb.The Journal of physiology · 2025Article
- Flexible control of motor units: is the multidimensionality of motor unit manifolds a sufficient condition?The Journal of physiology · 2025Article
- Higher dominant muscle strength is mediated by motor unit discharge rates and proportion of common synaptic inputs.Scientific reports · 2025Article
- Acute modulation of common synaptic inputs and motor unit discharge rates following neuromuscular electrical stimulation superimposed onto voluntary contractions.Frontiers in physiology · 2025Article
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Authors and funding
8 authors at 6 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of our study was to identify the low-dimensional latent components, defined hereafter as motor unit modes, underlying the discharge rates of the motor units in two knee extensors (vastus medialis and lateralis, eight men) and two hand muscles (first dorsal interossei and thenars, seven men and one woman) during submaximal isometric contractions. Factor analysis identified two independent motor unit modes that captured most of the covariance of the motor unit discharge rates. We found divergent distributions of the motor unit modes for the hand and vastii muscles. On average, 75% of the motor units for the thenar muscles and first dorsal interosseus were strongly correlated with the module for the muscle in which they resided. In contrast, we found a continuous distribution of motor unit modes spanning the two vastii muscle modules. The proportion of the muscle-specific motor unit modes was 60% for vastus medialis and 45% for vastus lateralis. The other motor units were either correlated with both muscle modules (shared inputs) or belonged to the module for the other muscle (15% for vastus lateralis). Moreover, coherence of the discharge rates between motor unit pools was explained by the presence of shared synaptic inputs. In simulations with 480 integrate-and-fire neurons, we demonstrate that factor analysis identifies the motor unit modes with high levels of accuracy. Our results indicate that correlated discharge rates of motor units that comprise motor unit modes arise from at least two independent sources of common input among the motor neurons innervating synergistic muscles.
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