Evidence map›Paper›PMID 36922022›Full record

ArticleBritish journal of haematology2023

Baseline metabolic tumour burden improves risk stratification in Hodgkin lymphoma: A Children's Oncology Group study.

Sarah A Milgrom, Jihyun Kim, Qinglin Pei, Inki Lee, Bradford S Hoppe, Yue Wu, David Hodgson, Sandy Kessel, Kathleen M McCarten, Kenneth Roberts and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Prognostic value of baselineQuantitative imaging in medicine and surgery · 2026
    Article
  5. Observational
  6. Review
  7. Prognostic value of baseline and interim [European journal of nuclear medicine and molecular imaging · 2024
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Sarah A MilgromDepartment of Radiation Oncology, University of Colorado, Aurora, Colorado, USA.ORCID 0000-0003-0037-6967
Jihyun KimDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Qinglin PeiChildren's Oncology Group, Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
Inki LeeDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Bradford S HoppeDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, Florida, USA.ORCID 0000-0002-2312-5418
Yue WuChildren's Oncology Group, Statistics and Data Center, Department of Biostatistics, University of Florida, Gainesville, Florida, USA.
David HodgsonUniversity of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4687-4582
Sandy KesselImaging and Radiation Oncology Core, Lincoln, Rhode Island, USA.
Kathleen M McCartenImaging and Radiation Oncology Core, Lincoln, Rhode Island, USA.
Kenneth RobertsYale University School of Medicine, New Haven, Connecticut, USA.
Andrea C LoBC Cancer Agency, Vancouver, British Columbia, Canada.ORCID 0000-0002-3253-1071
Peter D ColeRutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Kara M KellyPediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0003-1473-3937
Steve Y ChoDivision of Nuclear Medicine and Molecular Imaging, Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USUniversity of Florida · USBC Cancer Agency · CAJacksonville College · USRoswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Toronto · CAYale University · US

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Children's Oncology Group Statistics &Data Center GrantU10CA098413 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DEVIDAS, MEENAKSHI · 2003 to 2013
$67.5M
QUALITY ASSURANCE REVIEW CENTER (QARC)U10CA029511 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, THOMAS J. · 1985 to 2013
$23.4M
NCI NIH HHS U10 CA029511NCI NIH HHS U10 CA098413NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NCI NIH HHS U24 CA180803
6 · The paper itself

Abstract

The Children's Oncology Group AHOD0831 study used a positron emission tomography (PET) response-adapted approach in high-risk Hodgkin lymphoma, whereby slow early responders (SERs) received more intensive therapy than rapid early responders (RERs). We explored if baseline PET-based characteristics would improve risk stratification. Of 166 patients enrolled in the COG AHOD0831 study, 94 (57%) had baseline PET scans evaluable for quantitative analysis. For these patients, total body metabolic tumour volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV

Indexed as

Hodgkin DiseaseChildFluorodeoxyglucose F18GlycolysisHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyPrognosisRadiopharmaceuticalsRetrospective StudiesRisk AssessmentTumor BurdenFluorodeoxyglucose F18RadiopharmaceuticalsHodgkin diseaseHodgkin's lymphomametabolic tumor volumePETtotal lesion glycolysis

Identifiers

PMID36922022
PMCPMC10247420
OpenAlexW4324318067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.