Evidence map›Paper›PMID 36921989›Full record

ArticleBMJ global health2023

Where are the missing people affected by tuberculosis? A programme review of patient-pathway and cascade of care to optimise tuberculosis case-finding, treatment and prevention in Cambodia.

Alvin Kuo Jing Teo, Fukushi Morishita, Kiesha Prem, Sothearith Eng, Yom An, Chan Yuda Huot, Kim Eam Khun, Sivanna Tieng, Serongkea Deng, Sovannary Tuot and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ global health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Population-wide active case finding as a strategy to end TB.The Lancet regional health. Western Pacific · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 7 countries.

Alvin Kuo Jing Teo *Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Fukushi Morishita *World Health Organization Regional Office for the Western Pacific, Manila, Philippines.
Kiesha Prem *Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Sothearith EngKHANA Center for Population Health Research, Phnom Penh, Cambodia.
Yom AnSchool of Health Sciences, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Chan Yuda HuotNational Center for Tuberculosis and Leprosy Control (CENAT), Phnom Penh, Cambodia.
Kim Eam KhunNational Center for Tuberculosis and Leprosy Control (CENAT), Phnom Penh, Cambodia.
Sivanna TiengNational Center for Tuberculosis and Leprosy Control (CENAT), Phnom Penh, Cambodia.
Serongkea DengWorld Health Organization Cambodia Representative Office, Phnom Penh, Cambodia.
Sovannary TuotKHANA Center for Population Health Research, Phnom Penh, Cambodia.
Siyan YiSaw Swee Hock School of Public Health, National University of Singapore, Singapore siyan@nus.edu.sg.
Cambodia National Malaria Center · KHLondon School of Hygiene & Tropical Medicine · GBNational University of Singapore · SGThe University of Tokyo · JPTouro University California · USUniversity of the Ryukyus · JPUniversity of Tsukuba · JPWorld Health Organization Regional Office for the Western Pacific · PH

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundCambodia has achieved great success in tuberculosis (TB) control in the past decade. Nevertheless, people with TB are missed by the health systems at different stages of the care pathway. This programme review corroborated the care-seeking behaviours of people with TB and TB services availability and estimated the number of people completing each step of the TB disease and TB preventive treatment (TPT) care cascade.

methodsPatient pathways and the care cascades for TB disease and TPT were constructed using data from the latest national TB prevalence survey, routine surveillance and programme, the global TB database and published studies. We also randomly selected TB survivors in the 2019 cohort to assess recurrence-free survival 1-year post-treatment. TPT care cascade was constructed for people living with HIV (PLHIV) and household contacts (children <5 years and all ages) of persons with bacteriologically-confirmed TB in 2019 and 2020.

resultsNationally, 54% of those who exhibited TB symptoms sought initial care in the private sector. Overall, 93% and 58% of people with presumptive TB did not access a facility with TB diagnostic and treatment services, respectively, at the first point of care-seeking. Approximately 56% (95% CI 52% to 57%) of the 47 000 (95% CI 31 000 to 68 000) estimated TB cases in 2019 achieved recurrence-free survival. Among the estimated PLHIV in Cambodia, <30% completed TPT. Among children <5 years, 53% (95% CI 29% to 65%) (2019) and 67% (95% CI 36% to 80%) (2020) of those eligible for TPT completed the regimen successfully. In 2019 and 2020, 23% (95% CI 22% to 25%) and 54% (95% CI 50% to 58%) of the estimated household contacts (all ages) eligible for TPT completed the regimen successfully.

conclusionThere are significant gaps in care-seeking, coverage and access to TB services and TPT in Cambodia. Action plans to improve TB response have been co-developed with local stakeholders to address the gaps throughout the care cascades.

Indexed as

TuberculosisCambodiaChildHumansPrevalencetuberculosis

Identifiers

PMID36921989
PMCPMC10030488
OpenAlexW4324350781

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.