ArticleBMJ open2023
Association between maternal multimorbidity and preterm birth, low birth weight and small for gestational age: a prospective birth cohort study from the Japan Environment and Children's Study.
Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Global prevalence of multimorbidity during pregnancy: a systematic review and meta-analysis.Reproductive health · 2026Pooled it
- Perinatal and neonatal outcomes among women with multimorbidity during pregnancy globally: a systematic review.BMC pediatrics · 2026Pooled it
- Association between maternal multimorbidity and preterm birth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Pregnancy with multiple high-risk factors: a systematic review and meta-analysis.Journal of global health · 2025Pooled it
- Racial Disparities and Comorbidities: Network Analysis of Maternal Outcomes in Alabama.Journal of racial and ethnic health disparities · 2026Article
- Maternal multimorbidity, lifestyle behaviours during pregnancy, and early-childhood growth trajectories: a register-based cohort study.The Lancet regional health. Western Pacific · 2026Article
- Multiple Maternal Chronic Conditions and Risk of Severe Neonatal Morbidity and Mortality.JAMA network open · 2026Article
- Characteristics and Outcomes of Rapid Response System Activations in Obstetric Patients: A Multicenter Registry-Based Study in Japan.Journal of multidisciplinary healthcare · 2026Article
- Multimorbidity before, during and after pregnancy among women in low-income and middle-income countries: protocol for a scoping review.BMJ open · 2025Article
- Analyzing electronic medical records to extract prepregnancy morbidities and pregnancy complications: Toward a learning health system.Learning health systems · 2025Article
- Article
- Burden of multiple high-risk factors in pregnancy before and after the universal two-child policy in Chinese women: An observational study.Journal of global health · 2024Observational
- Factors Associated with Spontaneous Preterm Birth after Ultrasound-Indicated Cerclage.Journal of personalized medicine · 2023Article
- Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study.BMC medicine · 2023Observational
- Maternal multimorbidity and chronic conditions as predictors of preterm birth: A matched case-control study in Cyprus.Journal of multimorbidity and comorbidityArticle
Corrections and comments
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesMultimorbidity is defined as the coexistence of two or more chronic physical or psychological conditions within an individual. The association between maternal multimorbidity and adverse perinatal outcomes such as preterm delivery and low birth weight has not been well studied. Therefore, this study aimed to investigate this association.
methodsWe conducted a prospective cohort study using data from the Japan Environment and Children's Study of pregnant women between 2011 and 2014. Those with data on chronic maternal conditions were included in the study and categorised as having no chronic condition, one chronic condition or multimorbidities. The primary outcomes were the incidence of preterm birth (PTB), low birth weight (LBW) and small for gestational age (SGA). Adjusted logistic regression was performed to estimate ORs (aORs) and 95% CIs.
resultsOf the 104 062 fetal records, 86 885 singleton pregnant women were analysed. The median maternal age and body mass index were 31 years and 20.5 kg/m
conclusionMaternal multimorbidity was associated with adverse perinatal outcomes, including PTB, LBW and SGA. The risk of adverse perinatal outcomes tends to increase with a rise in the number of chronic maternal conditions. Multimorbidity becomes more prevalent among pregnant women, making our findings important for preconception counselling.
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