ArticleNature2023
Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
40.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 191 citations in OpenAlex.
- Lactate Signal: Modulator of Cellular Energy Production and Anabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Malic enzyme 1 senses L-lactate to determine tumor heterogeneity.Signal transduction and targeted therapy · 2026Article
- The diversity of terminal electron acceptors across eukaryotes.Trends in biochemical sciences · 2026Review
- Lactate Metabolism: Separating Correlation From Causation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death.Cell metabolism · 2026Article
- ZDHHC17-Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Metabolite-mediated plant immunity: From traditional defenders to artificial elicitors.Journal of integrative plant biology · 2026Review
- Spatial control of mitochondrial retrograde signaling by nuclear pore-associated contact sites.bioRxiv : the preprint server for biology · 2026Article
- Lactate Biology: Subcellular Routing and Chemical Form Define Function.Biochemistry · 2026Review
- Article
- A bioenergetic understanding of "aerobic glycolysis".Communications biology · 2026Review
- Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells.The Journal of biological chemistry · 2026Article
- Article
- DHX9 transcriptional upregulation and lactylation at K1024 fuels a glycolysis-histone lactylation loop in osteosarcoma.Journal of translational medicine · 2026Article
- Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Lactate as a Chemical Modification on Proteins and Metabolites.Annual review of biochemistry · 2026Review
- Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Development and validation of an interpretable prognostic model for bladder cancer based on lactylation associated genes using SHAP analysis.Discover oncology · 2026Article
- Association of serum lactate dehydrogenase levels with the severity of microvascular invasion in hepatocellular carcinoma: a retrospective cross-sectional study.Journal of gastrointestinal oncology · 2026Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 3 countries.
Weihai Liu *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Yun Wang *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Luiz H M Bozi *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Patrick D Fischer *Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4160-5295
Mark P JedrychowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Haopeng XiaoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4166-647X
Tao WuDepartment of Systems Biology, Harvard Medical School, Boston, MA, USA.
Narek DarabedianDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xiadi HeDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Evanna L MillsDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0447-8995
Nils BurgerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3227-8894
Sanghee ShinDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Anita ReddyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hans-Georg SprengerDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nhien TranDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sally WintherDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Stephen M HinshawStanford Cancer Institute, School of Medicine, Stanford University, Stanford, CA, USA.
Jingnan ShenDepartment of Musculoskeletal Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Hyuk-Soo SeoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0646-2102
Kijun SongDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6037-9345
Andrew Z XuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Luke SebastianDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6863-9420
Jean J ZhaoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4561-5688
Sirano Dhe-PaganonDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0824-5929
Jianwei CheDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Haribabu ArthanariDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Edward T ChouchaniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. edwardt_chouchani@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-9776-8790
Harvard University · USDana-Farber Cancer Institute · USBroad Institute · USStanford University · USSun Yat-sen University · CN
Funding
Determining mechanisms of the succinate thermogenesis pathways on UCP1-dependent and UCP1-independent thermogenesisR01DK123095 · NIDDK · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2019 to 2026
$4.2MDefining the landscape and mechanisms of protein redox regulation during agingR01AG071966 · NIA · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2022 to 2026
$2.9MCancer Chemical Biology and Metabolism Training ProgramT32CA236754 · NCI · DANA-FARBER CANCER INST · PI Nika N Danial, THOMAS M ROBERTS · 2019 to 2026
$2.6MDefining the landscape and mechanisms of redox regulation of metabolism during agingK99AG073461 · NIA · DANA-FARBER CANCER INST · PI XIAO, HAOPENG · 2022 to 2023
$220kNCI NIH HHS T32 CA236754NIA NIH HHS K99 AG073461NIA NIH HHS R01 AG071966NIDDK NIH HHS R01 DK123095
Abstract
Lactate is abundant in rapidly dividing cells owing to the requirement for elevated glucose catabolism to support proliferation
Indexed as
Anaphase-Promoting Complex-CyclosomeCell CycleCell Cycle ProteinsLactic AcidAnaphaseApc4 Subunit, Anaphase-Promoting Complex-CyclosomeCysteine EndopeptidasesHumansMitosisUbiquitin-Conjugating EnzymesANAPC4 protein, humanAnaphase-Promoting Complex-CyclosomeApc4 Subunit, Anaphase-Promoting Complex-CyclosomeCell Cycle ProteinsCysteine EndopeptidasesLactic AcidSENP1 protein, humanUBE2C protein, humanUbiquitin-Conjugating Enzymes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.