Evidence map›Paper›PMID 36921605›Full record

ArticleCurrent biology : CB2023

Volume-transmitted GABA waves pace epileptiform rhythms in the hippocampal network.

Vincent Magloire, Leonid P Savtchenko, Thomas P Jensen, Sergyi Sylantyev, Olga Kopach, Nicholas Cole, Olga Tyurikova, Dimitri M Kullmann, Matthew C Walker, Jonathan S Marvin and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Equal levels of pre- and postsynaptic potentiation produce unequal outcomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  8. Article
  9. Article
  10. Avoiding bias in fluorescence sensor readout.Nature reviews. Neuroscience · 2024
    Article
  11. Review
  12. Review
  13. Microscale Neuronal Activity Collectively Drives Chaotic and Inflexible Dynamics at the Macroscale in Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Vincent MagloireUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: v.magloire@ucl.ac.uk.
Leonid P SavtchenkoUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: leonid.savtchenko@ucl.ac.uk.
Thomas P JensenUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Sergyi SylantyevUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK; Rowett Institute, University of Aberdeen, Ashgrove Road West, Aberdeen AB25 2ZD, UK.
Olga KopachUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Nicholas ColeUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Olga TyurikovaUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Dimitri M KullmannUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Matthew C WalkerUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Jonathan S MarvinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Loren L LoogerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA; GENIE Project Team, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Jeremy P HassemanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; GENIE Project Team, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Ilya KolbJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA; GENIE Project Team, Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Ivan PavlovUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
Dmitri A RusakovUCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address: d.rusakov@ucl.ac.uk.
National Hospital for Neurology and Neurosurgery · GBHoward Hughes Medical Institute · USQueen Mary University of London · GB

Funding

European Research Council 323113Medical Research Council G0400136Medical Research Council G0400627Medical Research Council G0801316Medical Research Council MR/V013556/1Medical Research Council MR/V034758/1Medical Research Council MR/W005204/1Medical Research Council MR/W019752/1MRF_ MRF-007-0004-STD-KULLMNational Centre for the Replacement, Refinement and Reduction of Animals in Research NC/X001067/1Wellcome Trust 101896Wellcome Trust 209807/Z/17/ZWellcome Trust 212251Wellcome Trust 212251/Z/18/ZWellcome Trust 212285/Z/18/ZWellcome Trust 223131
6 · The paper itself

Abstract

Mechanisms that entrain and pace rhythmic epileptiform discharges remain debated. Traditionally, the quest to understand them has focused on interneuronal networks driven by synaptic GABAergic connections. However, synchronized interneuronal discharges could also trigger the transient elevations of extracellular GABA across the tissue volume, thus raising tonic conductance (G

Indexed as

HippocampusSynaptic Transmissiongamma-Aminobutyric AcidInterneuronsNeuronsgamma-Aminobutyric Acidbrain rhythmsepilepsyextracellular GABAGABA uptakeGAT-1iGABASnFR2spiking neural networkstonic GABA conductancevolume transmission

Identifiers

PMID36921605
PMCPMC10615848
OpenAlexW4324354239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.