Evidence map›Paper›PMID 36921569›Full record

ArticleImmunity2023

STeerING PI4P for innate immune activation.

Chao Qin, Shu Feng, Pinghui Feng

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Apolipoproteins L involvement in immunity.Journal of human immunity · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chao QinSection of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA.
Shu FengDepartment of Diabetes & Cancer Metabolism, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Pinghui FengSection of Infection and Immunity, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA; Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Los Angeles, CA, USA. Electronic address: pinghuif@usc.edu.
University of Southern California · USBeckman Research Institute

Funding

Explore roles of HSV-1 in Alzheimer's disease using mouse modelsR01AG070904 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, CASEY, FENG, PINGHUI · 2021 to 2025
$3.9M
NFAT activation in kGPCR tumorigenesisR01CA221521 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FENG, PINGHUI · 2017 to 2021
$1.9M
NCI NIH HHS R01 CA221521NIA NIH HHS R01 AG070904
6 · The paper itself

Abstract

STING transverses the endoplasmic reticulum (ER), Golgi, and endosomal compartments before its degradation within the lysosomes. In this issue of Immunity, Fang et al. demonstrate that the enrichment of cholesterol and sphingomyelin in the trans-Golgi network and endosomes mediated by the ARMH3-PI4KB-PI4P pathway plays a pivotal role in STING activation under cGAS-dependent and -independent conditions.

Indexed as

Golgi ApparatusNucleotidyltransferasesEndosomesImmunity, InnateLysosomesNucleotidyltransferases

Identifiers

PMID36921569
OpenAlexW4324195783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.