Evidence map›Paper›PMID 36921327›Full record

ReviewAdvanced healthcare materials2023

3D Bioprinting in Otolaryngology: A Review.

Alexandra McMillan, Nadia McMillan, Nikesh Gupta, Sohit P Kanotra, Aliasger K Salem

Open access · bronzeAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Bioprinting for craniofacial reconstruction: A review of advancements, clinical use, and challenges.Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery · 2025
    Review
  4. Article
  5. Article
  6. [Research progress of three-dimensional bioprinting technology in auricle repair and reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alexandra McMillanDepartment of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52252, USA.ORCID 0000-0002-5648-2016
Nadia McMillanDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Nikesh GuptaDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.
Sohit P KanotraDepartment of Otolaryngology, University of Iowa Hospitals and Clinics, Iowa City, IA, 52252, USA.
Aliasger K SalemDepartment of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, 52242, USA.ORCID 0000-0002-1923-6633
University of Iowa · USBeth Israel Deaconess Medical Center · USUniversity of Iowa Hospitals and Clinics · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
CST6-mRNA activated matrices for efficient bone regenerationR21DE031042 · NIDCR · UNIVERSITY OF IOWA · PI SALEM, ALIASGER K · 2022 to 2023
$425k
NIDCR NIH HHS R21 DE031042NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

The evolution of tissue engineering and 3D bioprinting has allowed for increased opportunities to generate musculoskeletal tissue grafts that can enhance functional and aesthetic outcomes in otolaryngology-head and neck surgery. Despite literature reporting successes in the fabrication of cartilage and bone scaffolds for applications in the head and neck, the full potential of this technology has yet to be realized. Otolaryngology as a field has always been at the forefront of new advancements and technology and is well poised to spearhead clinical application of these engineered tissues. In this review, current 3D bioprinting methods are described and an overview of potential cell types, bioinks, and bioactive factors available for musculoskeletal engineering using this technology is presented. The otologic, nasal, tracheal, and craniofacial bone applications of 3D bioprinting with a focus on engineered graft implantation in animal models to highlight the status of functional outcomes in vivo; a necessary step to future clinical translation are reviewed. Continued multidisciplinary efforts between material chemistry, biological sciences, and otolaryngologists will play a key role in the translation of engineered, 3D bioprinted constructs for head and neck surgery.

Indexed as

BioprintingOtolaryngologyAnimalsCartilagePrinting, Three-DimensionalTissue EngineeringTissue Scaffolds3D-printingbioprintinghead and neck surgeryotolaryngologytissue engineering

Identifiers

PMID36921327
PMCPMC10502192
OpenAlexW4324320305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.