ArticleAmerican journal of respiratory and critical care medicine2023
Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00037765 (Gene Modifiers of Cystic Fibrosis Lung Disease), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gene Modifiers of Cystic Fibrosis Lung Disease
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Impact of Gene Modifiers on Cystic Fibrosis Phenotypic Profiles: A Systematic Review.Human mutation · 2024Pooled it
- Impact of Genetics on Endocrine Manifestations of Cystic Fibrosis.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026Review
- Genetic variants in pulmonary hypertension associated with chronic obstructive pulmonary disease.Current opinion in pulmonary medicine · 2026Review
- A global map for introgressed structural variation and selection in humans.Science (New York, N.Y.) · 2026Article
- Computational framework for therapeutic target discovery via perturbation simulation: application to cystic fibrosis airway disease.Briefings in bioinformatics · 2026Article
- Role of theInternational journal of molecular sciences · 2025Article
- Role of S1PR1 in Modulating Airway Epithelial Responses toPathogens (Basel, Switzerland) · 2025Article
- Human induced pluripotent stem cells for in vitro modeling of impaired mucociliary clearance in cystic fibrosis lung disease.Stem cell research & therapy · 2025Article
- Evaluation of Alpha1 Antitrypsin Deficiency-Associated Mutations in People with Cystic Fibrosis.Journal of clinical medicine · 2025Article
- Diagnosis and Emerging Biomarkers of Cystic Fibrosis-Related Kidney Disease (CFKD).Journal of clinical medicine · 2025Review
- A stem cell-based platform for functional analysis of genetic variants in lung disease.bioRxiv : the preprint server for biology · 2025Article
- mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node.Orphanet journal of rare diseases · 2025Review
- Article
- Identifying novel therapeutic targets in cystic fibrosis through advanced single-cell transcriptomics analysis.Computers in biology and medicine · 2025Article
- The Cystic Fibrosis Transmembrane Conductance Receptor Brakes Allergic Airway Inflammation.Immunological reviews · 2025Review
- Long G4-rich enhancers target promoters via a G4 DNA-based mechanism.Nucleic acids research · 2025Article
- Identification of Novel Modifier Genes Associated With Pain in Cystic Fibrosis: An In Silico Gene Discovery.Human mutation · 2025Article
- Recent advances in immunopathogenesis and clinical practice: mastering the challenge-managing of non-tuberculous mycobacteria.Frontiers in immunology · 2025Review
- Genetic modifiers of body mass index in individuals with cystic fibrosis.American journal of human genetics · 2024Article
- Genetics of chronic respiratory disease.Nature reviews. Genetics · 2024Review
Corrections and comments
- Commented on by
Authors and funding
30 authors at 13 institutions in 5 countries.
Yi-Hui ZhouBioinformatics Research Center.ORCID 0000-0002-4092-7463
Paul J GallinsBioinformatics Research Center.
Rhonda G PaceMarsico Lung Institute/UNC CF Research Center, School of Medicine.
Hong DangMarsico Lung Institute/UNC CF Research Center, School of Medicine.
Melis A AksitMcKusick-Nathans Department of Genetic Medicine.
Elizabeth E BlueBrotman Baty Institute for Precision Medicine, Seattle, Washington.
Kati J BuckinghamDivision of Genetic Medicine, Department of Pediatrics.
Joseph M CollacoEudowood Division of Pediatric Respiratory Sciences.
Anna V FainoChildren's Core for Biostatistics, Epidemiology and Analytics in Research and.
William W GordonDivision of Genetic Medicine, Department of Pediatrics.
Kurt N HetrickDepartment of Genetic Medicine, Center for Inherited Disease Research, and.
Hua LingDepartment of Genetic Medicine, Center for Inherited Disease Research, and.
Weifang LiuDepartment of Biostatistics.
Frankline M OnchiriChildren's Core for Biostatistics, Epidemiology and Analytics in Research and.
Kymberleigh PagelThe Institute for Computational Medicine, The Johns Hopkins University, Baltimore, Maryland.
Elizabeth W PughDepartment of Genetic Medicine, Center for Inherited Disease Research, and.
Karen S RaraighMcKusick-Nathans Department of Genetic Medicine.
Margaret RosenfeldDepartment of Pediatrics, and.
Quan SunDepartment of Biostatistics.
Jia WenDepartment of Genetics, and.
Yun LiDepartment of Biostatistics.
Harriet CorvolPediatric Pulmonary Department, Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Paris, France.
Lisa J StrugDivision of Biostatistics, Dalla Lana School of Public Health.
Michael J BamshadBrotman Baty Institute for Precision Medicine, Seattle, Washington.
Scott M BlackmanMcKusick-Nathans Department of Genetic Medicine.ORCID 0000-0002-4532-6421
Garry R CuttingMcKusick-Nathans Department of Genetic Medicine.
Ronald L GibsonDepartment of Pediatrics, and.
Wanda K O'NealMarsico Lung Institute/UNC CF Research Center, School of Medicine.
Fred A WrightBioinformatics Research Center.
Michael R KnowlesMarsico Lung Institute/UNC CF Research Center, School of Medicine.
Lung Institute · USCenter for Inherited Blood Disorders · USCancer Research And Biostatistics · USJohns Hopkins University · USPediatrics and Genetics · USSeattle Children's Hospital · USTranslational Research Informatics Center (Japan) · JP3M (United States) · USInserm · FRMedical Genetics Center · DENorth Carolina State University · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US
Funding
NHLBI Data Stage Coordinating CenterOT3HL147154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ashok Kumar Krishnamurthy · 2018 to 2026
$98.9MVector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Scott H Randell · 2004 to 2026
$26.5MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142481 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GROSSMAN, ROBERT L., PATEN, BENEDICT · 2017 to 2020
$24.9MTranslational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142478 · NHLBI · SEVEN BRIDGES GENOMICS, INC. · PI DAVIS-DUSENBERY, BRANDI NICOLE · 2017 to 2022
$12.6MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142480 · NHLBI · HARVARD MEDICAL SCHOOL · PI AVILLACH, PAUL · 2017 to 2022
$8.8MThe Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142479 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KRISHNAMURTHY, ASHOK KUMAR · 2017 to 2020
$6.1MNHLBI NIH HHS OT3 HL142478NHLBI NIH HHS OT3 HL142479NHLBI NIH HHS OT3 HL142480NHLBI NIH HHS OT3 HL142481NHLBI NIH HHS OT3 HL147154NIDDK NIH HHS P30 DK065988NIDDK NIH HHS P30 DK089507
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorGenome-Wide Association StudyHumansLungMicrotubule-Associated ProteinsPatient AcuityCEP72 protein, humanCystic Fibrosis Transmembrane Conductance RegulatorMicrotubule-Associated Proteinscystic fibrosisGWAS/TWASlung disease severitypathway analyseswhole-genome sequencing
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00037765ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.