Evidence map›Paper›PMID 36920991›Full record

ArticlePloS one2023

Healthcare seeking patterns for TB symptoms: Findings from the first national TB prevalence survey of South Africa, 2017-2019.

Sizulu Moyo, Farzana Ismail, Nkateko Mkhondo, Martie van der Walt, Sicelo S Dlamini, Thuli Mthiyane, Inbarani Naidoo, Khangelani Zuma, Marina Tadolini, Irwin Law and 1 more

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Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Asymptomatic Tuberculosis in Children With Household Exposure to Mycobacterium tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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  6. Oral Rinse versus Facemask Capture for Nonsputum Diagnosis of Pulmonary Tuberculosis.American journal of respiratory and critical care medicine · 2025
    Article
  7. Article
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  11. Article
  12. Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali.Journal of clinical tuberculosis and other mycobacterial diseases · 2023
    Article
  13. Article
  14. Article
  15. Clinical standards for drug-susceptible pulmonary TB.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  16. Article
  17. Early mortality during rifampicin-resistant TB treatment.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2022
    Article
  18. Article
  19. Diagnosis patterns for rifampicin-resistant TB after onset of COVID-19.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sizulu MoyoHuman Sciences Research Council, Cape Town, South Africa.ORCID 0000-0002-5296-3242
Farzana IsmailNational Institute for Communicable Diseases Division of the National Health Laboratory Services, Johannesburg, South Africa.
Nkateko MkhondoTuberculosis Programme, World Health Organization, Pretoria, South Africa.
Martie van der WaltSouth African Medical Research Council, Pretoria, South Africa.
Sicelo S DlaminiNational Department of Health, Pretoria, South Africa.
Thuli MthiyaneSouth African Medical Research Council, Pretoria, South Africa.
Inbarani NaidooHuman Sciences Research Council, Cape Town, South Africa.
Khangelani ZumaHuman Sciences Research Council, Cape Town, South Africa.
Marina TadoliniInfectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Irwin LawGlobal Tuberculosis Programme, World Health Organization, Geneva, Switzerland.ORCID 0000-0002-1194-677X
Lindiwe MvusiNational Department of Health, Pretoria, South Africa.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundAlthough tuberculosis (TB) symptoms have limited sensitivity they remain an important entry point into the TB care cascade.

objectivesTo investigate self-reported healthcare seeking for TB symptoms in participants in a community-based survey.

methodsWe compared reasons for not seeking care in participants reporting ≥1 of four TB screening symptoms (cough, weight loss, night sweats, fever) in the first South African national TB prevalence survey (2017-2019). We used logistic regression analyses to identify sociodemographic and clinical characteristics associated with healthcare seeking.

results5,168/35,191 (14.7%) survey participants reported TB symptoms and 3,442/5168 had not sought healthcare. 2,064/3,442(60.0%) participants intended to seek care, 912 (26.5%) regarded symptoms as benign, 399 (11.6%) reported access barriers(distance and cost), 36 (1.0%) took other medications and 20(0.6%) reported health system barriers. Of the 57/98 symptomatic participants diagnosed with bacteriologically confirmed TB who had not sought care: 38(66.7%) intended to do so, 8(14.0%) regarded symptoms as benign, and 6(10.5%) reported access barriers. Among these 98, those with unknown HIV status(OR 0.16 95% CI 0.03-0.82), p = 0.03 and those who smoked tobacco products(OR 0.39, 95% CI 0.17-0.89, p = 0.03) were significantly less likely to seek care.

conclusionsPeople with TB symptoms delayed seeking healthcare, many regarded symptoms as benign while others faced access barriers. Those with unknown HIV status were significantly less likely to seek care. Strengthening community-based TB awareness and screening programmes together with self-screening models could increase awareness of the significance of TB symptoms and contribute to improving healthcare seeking and enable many people with TB to enter the TB care cascade.

Indexed as

HIV InfectionsTuberculosisHumansPatient Acceptance of Health CarePrevalenceSouth Africa

Identifiers

PMID36920991
PMCPMC10016667

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read108
identifiers read4
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.