Evidence map›Paper›PMID 36920749›Full record

ArticleCEN case reports2023

IgA-dominant infection-related glomerulonephritis with NAPlr-positive tubulointerstitial nephritis.

Issei Okunaga, Shin-Ichi Makino, Daisuke Honda, Narihito Tatsumoto, Masashi Aizawa, Takashi Oda, Katsuhiko Asanuma

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in CEN case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Issei OkunagaDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.ORCID 0000-0002-7782-8207
Shin-Ichi MakinoDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Daisuke HondaDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Narihito TatsumotoDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Masashi AizawaDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan.
Takashi OdaDepartment of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 193-0998, Tokyo, Japan.
Katsuhiko AsanumaDepartment of Nephrology, Graduate School of Medicine, Chiba University, Chiba, 260-8670, Japan. kasanuma@chiba-u.jp.
Chiba University · JPTokyo Medical University Hachioji Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection-related glomerulonephritis (IRGN) is one of the most common causes of acute kidney injury (AKI). Positive glomerular staining of the nephritis-associated plasmin receptor (NAPlr) has been reported as a useful biomarker of IRGN. Although the infection can provoke acute tubulointerstitial nephritis (AIN), there are few reports of positive staining for NAPlr with AIN. We report a case of methicillin-sensitive Staphylococcus aureus (MSSA) infection-related nephritis complicated with AIN, which showed positive staining for tubulointerstitial NAPlr. The patient developed AKI and nephrotic syndrome during an intraperitoneal MSSA infection. A diagnosis of IRGN complicated by infection-related acute tubulointerstitial nephritis (IRAIN) was made based on glomerular endocapillary proliferation with tubulointerstitial infiltrating cells and tubular atrophy. Tubulointerstitial infiltrating cells were positive for NAPlr staining and plasmin activity. Treatment of the infection by antibiotics and drainage did not improve the AKI, but steroid administration improved that. NAPlr evaluation is a helpful tool for identifying causes of AIN during infection.

Indexed as

Acute Kidney InjuryGlomerulonephritisGlomerulonephritis, IGANephritisNephritis, InterstitialStaphylococcal InfectionsHumansImmunoglobulin AReceptors, PeptideImmunoglobulin Aplasmin receptorReceptors, PeptideAcute kidney injuryInfection-related acute tubulointerstitial nephritisInfection-related glomerulonephritisMethicillin-sensitive Staphylococcus aureusNephritis-associated plasmin receptorNephrotic syndrome

Identifiers

PMID36920749
PMCPMC10620344
OpenAlexW4324303359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.