Evidence map›Paper›PMID 36920741›Full record

ArticleSpine deformity2023

Impact of implant metal type and vancomycin prophylaxis on postoperative spine infection: an in-vivo study.

Sachin Gupta, Sukanta Maitra, Ali S Farooqi, Kavita Gupta, Pumibal Wetpiriyakul, Maria Pereira, Blythe Durbin-Johnson, Munish C Gupta

Abstract read
PubMed Publisher
In one paragraph

Article in Spine deformity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Sachin GuptaDepartment of Orthopaedic Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA. sagupta017@gmail.com.
Sukanta MaitraDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
Ali S FarooqiDepartment of Orthopaedic Surgery, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7763-6152
Kavita GuptaDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
Pumibal WetpiriyakulDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
Maria PereiraDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
Blythe Durbin-JohnsonDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
Munish C GuptaDepartment of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO, USA.
University of California, Davis · USHospital of the University of Pennsylvania · USUniversity of Pennsylvania · USWashington University in St. Louis · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR000002 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2012 to 2015
$12.2M
NCATS NIH HHS UL1 TR000002
6 · The paper itself

Abstract

purposeTo evaluate the effectiveness of vancomycin prophylaxis on spinal implant metal types.

methods42 rabbits underwent posterior, single-level instrumentation at L5-L6 with stainless steel (n = 18), cobalt chrome (n = 12), or titanium (n = 12) wire. All implants were inoculated with 1 × 10

resultsIntrawound vancomycin significantly reduced the rate of soft tissue infection (44.4% vs 100%) and implant infection (27.8% vs 100%) (p < 0.001). Within the intrawound vancomycin subgroup, cobalt chrome implants were associated with higher median soft tissue MRSA growth (130 CFU) than stainless steel (0 CFU) or titanium (0 CFU) (p = 0.02). Cobalt chrome implants were also more likely to develop soft tissue MRSA infection (83.3%) as compared to stainless steel (16.7%) or titanium (33.3%) (p = 0.04). Median soft tissue MRSA growth among stainless steel implants without prophylaxis, with IV vancomycin, and with vancomycin powder was 1.18 × 10

conclusionIntrawound vancomycin is more effective than IV vancomycin and effectively reduces the risk of infection, but is less effective in cobalt chrome implants due to residual soft tissue infection.

Indexed as

Methicillin-Resistant Staphylococcus aureusProsthesis-Related InfectionsSoft Tissue InfectionsSpinal DiseasesAnimalsAnti-Bacterial AgentsCobaltPowdersRabbitsStainless SteelTitaniumVancomycinAnti-Bacterial AgentsCobaltPowdersStainless SteelTitaniumVancomycinAntibioticCobaltImplantInfectionIn vivoMetalMRSAStainless steelStaphTitaniumVancomycin

Identifiers

PMID36920741
OpenAlexW4324311315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.