Evidence map›Paper›PMID 36920536›Full record

ArticleArchives of microbiology2023

Oral microbiome variations related to ageing: possible implications beyond oral health.

Alisa Kazarina, Jevgenija Kuzmicka, Santa Bortkevica, Pawel Zayakin, Janis Kimsis, Viktorija Igumnova, Darja Sadovska, Lauma Freimane, Agnija Kivrane, Agne Namina and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Archives of microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 50 citations in OpenAlex.

  1. [Research Advances on the Role of the Oral Microbiota in Age-Related Homeostatic Dysregulation and Systemic Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  2. Impact of probiotic, prebiotic, and synbiotic supplementation on the gut microbiome in older adults with sarcopenia, obesity, and sarcopenic obesity.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Alisa KazarinaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia. alisa.kazarina@biomed.lu.lv.ORCID http://orcid.org/0000-0003-3602-5261
Jevgenija KuzmickaRiga Stradins University, 16 Dzirciema Str., Riga, LV-1007, Latvia.ORCID http://orcid.org/0000-0003-4871-6414
Santa BortkevicaRiga Stradins University, 16 Dzirciema Str., Riga, LV-1007, Latvia.ORCID http://orcid.org/0000-0001-7884-5263
Pawel ZayakinLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Janis KimsisLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Viktorija IgumnovaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Darja SadovskaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Lauma FreimaneLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Agnija KivraneLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Agne NaminaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Valentina CapliginaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Alise PoksaneLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Renate RankaLaboratory of Molecular Biology, Latvian Biomedical Research and Study Centre, 1 Ratsupites Str., Riga, LV-1067, Latvia.
Latvian Biomedical Research and Study Centre · LVRiga Stradiņš University · LV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global population is getting older due to a combination of longer life expectancy and declining birth rates. Growing evidence suggests that the oral microbiota composition and distribution may have a profound effect on how well we age. The purpose of this study was to investigate age-related oral microbiome variations of supragingival plaque and buccal mucosa samples in the general population in Latvia. Our results indicated significant difference between supragingival plaque bacterial profiles of three age groups (20-40; 40-60; 60 + years). Within supragingival plaque samples, age group 20-40 showed the highest bacterial diversity with a decline during the 40-60 age period and uprise again after the age of 60. Among other differences, the important oral commensal Neisseria had declined after the age of 40. Additionally, prevalence of two well-documented opportunistic pathogens Streptococcus anginosus and Gemella sanguinis gradually rose with age within our samples. Furthermore, supragingival plaque and buccal mucosa samples significantly differed in overall bacterial composition.

Indexed as

MicrobiotaOral HealthAgingBacteriaCluster AnalysisHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16SAgeingHuman microbiomeLife spanMetagenomicsMicrobiotaOral microbiome

Identifiers

PMID36920536
PMCPMC10016173
OpenAlexW4324303535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.