Evidence map›Paper›PMID 36920216›Full record

ArticleJournal of bacteriology2023

Elucidation of the DNA-Binding Activity of VirF from Shigella flexneri for the

Garrett T Dow, Anna M Young, George A Garcia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. A Tale aboutMicroorganisms · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Garrett T DowDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Anna M YoungDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
George A GarciaDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
University of Michigan–Ann Arbor · US

Funding

INTERDEPARTMENTAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM007767 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ISOM, LORI L. · 1985 to 2019
$10.2M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM007767
6 · The paper itself

Abstract

A novel approach to treat the highly virulent and infectious enteric pathogen Shigella flexneri, with the potential for reduced resistance development, is to target virulence pathways. One promising such target is the AraC-family transcription factor VirF, which activates downstream virulence factors. VirF harbors a conserved C-terminal DNA-binding domain (DBD) and an N-terminal dimerization domain (NTD). Previously, we studied the wild type (WT) and seven alanine DBD mutants of VirF binding to the

Indexed as

DNA-Binding ProteinsShigella flexneriAraC Transcription FactorBacterial ProteinsDNAGene Expression Regulation, BacterialHumansInterferon Regulatory FactorsTranscription, GeneticViral ProteinsVirulence FactorsAraC Transcription FactorBacterial ProteinsDNADNA-Binding ProteinsInterferon Regulatory Factorsviral interferon regulatory factorsViral ProteinsVirulence FactorsDNA-protein interactionpathogenesisvirulence factors

Identifiers

PMID36920216
PMCPMC10127635
OpenAlexW4324304877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.