Evidence map›Paper›PMID 36920200›Full record

ArticleInfection and immunity2023

Effects of Low-Level Persistent Infection on Maintenance of Immunity by CD4 T Cell Subsets and Th1 Cytokines.

Samad A Ibitokou, Komi Gbedande, Michael M Opata, Victor H Carpio, Karis M Marshall, Robin Stephens

Open access · hybridFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Samad A Ibitokou *Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-7760-7412
Komi Gbedande *Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0002-3229-5566
Michael M OpataDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.
Victor H CarpioMicrobiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Karis M MarshallDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.
Robin StephensDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA.ORCID 0000-0001-8036-600X
The University of Texas Medical Branch at Galveston · US

Funding

The Germinal Center and T cell help in Three Phases of Clearance of PlasmodiumR01AI135061 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEPHENS, ROBIN · 2018 to 2022
$2.0M
Maintenance vs Programming in Th1 Memory Cell Development in P. Chabaudi MalariaR01AI089953 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEPHENS, ROBIN · 2011 to 2015
$1.8M
Regulation of Cellular and Humoral Responses to Mouse MalariaF31AI126809 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CARPIO ROJAS, VICTOR HUGO · 2017 to 2018
$38k
NIAID NIH HHS F31 AI126809NIAID NIH HHS R01 AI089953NIAID NIH HHS R01 AI135061
6 · The paper itself

Abstract

CD4 T cells are required, along with antibodies, for complete protection from blood-stage infection with Plasmodium spp., which cause malaria. Without continuous exposure, as on emigration of people from endemic areas, protection from malaria decays. As in other persistent infections, low-level Plasmodium chabaudi infection protects the host from reinfection at 2 months postinfection, a phenomenon termed premunition. Premunition is correlated with T cell responses, rather than antibody levels. We previously showed that while both effector T cells (Teff) and memory T cells (Tmem) are present after infection, Teff protect better than Tmem. Here, we studied T cell kinetics post-infection by labeling dividing

Indexed as

CytokinesMalariaAnimalsCD4-Positive T-LymphocytesInterferon-gammaInterleukin-2MicePersistent InfectionReinfectionTh1 CellsT-Lymphocyte SubsetsCytokinesInterferon-gammaInterleukin-2apicomplexan parasiteshelper T cellmalariaT-cell immunityTh1/Th2 responses

Identifiers

PMID36920200
PMCPMC10016079
OpenAlexW4322619337

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read27
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.