Evidence map›Paper›PMID 36920190›Full record

ArticleApplied and environmental microbiology2023

Liquid-Liquid Phase Separation of the DEAD-Box Cyanobacterial RNA Helicase Redox (CrhR) into Dynamic Membraneless Organelles in

Brendan T Whitman, Yixiong Wang, Cameron R A Murray, Mark J N Glover, George W Owttrim

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brendan T WhitmanDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Yixiong WangDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Cameron R A MurrayDepartment of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Mark J N GloverDepartment of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada.
George W OwttrimDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-4709-2091
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compartmentalization of macromolecules into discrete non-lipid-bound bodies by liquid-liquid phase separation (LLPS) is a well-characterized regulatory mechanism frequently associated with the cellular stress response in eukaryotes. In contrast, the formation and importance of similar complexes is just becoming evident in bacteria. Here, we identify LLPS as the mechanism by which the DEAD-box RNA helicase, cyanobacterial RNA helicase redox (CrhR), compartmentalizes into dynamic membraneless organelles in a temporal and spatial manner in response to abiotic stress in the cyanobacterium

Indexed as

SynechocystisBiomolecular CondensatesDEAD-box RNA HelicasesOrganellesOxidation-ReductionRNADEAD-box RNA HelicasesRNACrhR DEAD-box RNA helicasecyanobacteriaenvironmental regulationlaser scanning confocal immunofluorescence microscopy (LSCIM)liquid-liquid phase separation (LLPS)membraneless organelles

Identifiers

PMID36920190
PMCPMC10132119
OpenAlexW4324304881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.