Evidence map›Paper›PMID 36920076›Full record

ArticleACS applied materials & interfaces2023

Biodegradable Antibacterial Bioorthogonal Polymeric Nanocatalysts Prepared by Flash Nanoprecipitation.

Stefano Fedeli, Rui Huang, Yavuz Oz, Xianzhi Zhang, Aarohi Gupta, Sanjana Gopalakrishnan, Jessa Marie V Makabenta, Stephanie Lamkin, Amitav Sanyal, Yisheng Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefano FedeliDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Rui HuangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-1535-9804
Yavuz OzDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-3862-4420
Xianzhi ZhangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-9585-7458
Aarohi GuptaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0003-1303-1159
Sanjana GopalakrishnanDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Jessa Marie V MakabentaDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-2062-7914
Stephanie LamkinDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Amitav SanyalDepartment of Chemistry, Bogazici University, Istanbul 34342, Turkey.ORCID 0000-0001-5122-8329
Yisheng XuState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0000-0001-8245-9787
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.ORCID 0000-0002-5184-5439

Funding

Engineered Polymer Nanoemulsions for Treatment of Wound Biofilm InfectionsR01AI134770 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Robin Patel, VINCENT M. ROTELLO · 2018 to 2026
$3.5M
Targeting of Bio-orthogonal Chemotherapeutic Nanozymes to Tumor-Associated MacrophagesR01EB022641 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2017 to 2024
$3.0M
NIAID NIH HHS R01 AI134770NIBIB NIH HHS R01 EB022641
6 · The paper itself

Abstract

Bioorthogonal activation of pro-dyes and prodrugs using transition-metal catalysts (TMCs) provides a promising strategy for imaging and therapeutic applications. TMCs can be loaded into polymeric nanoparticles through hydrophobic encapsulation to generate polymeric nanocatalysts with enhanced solubility and stability. However, biomedical use of these nanostructures faces challenges due to unwanted tissue accumulation of nonbiodegradable nanomaterials and cytotoxicity of heavy-metal catalysts. We report here the creation of fully biodegradable nanocatalysts based on an engineered FDA-approved polymer and the naturally existing catalyst hemin. Stable nanocatalysts were generated through kinetic stabilization using flash nanoprecipitation. The therapeutic potential of these nanocatalysts was demonstrated through effective treatment of bacterial biofilms through the bioorthogonal activation of a pro-antibiotic.

Indexed as

NanoparticlesNanostructuresTransition ElementsAnti-Bacterial AgentsPolymersAnti-Bacterial AgentsPolymersTransition Elementsbiofilmsbioorthogonal chemistrybioresorbable polymersnanocatalystsnanozymestransition-metal catalysts (TMCs)

Identifiers

PMID36920076
PMCPMC10699753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.