Evidence map›Paper›PMID 36919632›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Design and biological evaluation of 3-substituted quinazoline-2,4(1

Abdelfattah Hassan, Fawzy A F Mubarak, Ihsan A Shehadi, Ahmed M Mosallam, Hussain Temairk, Mohamed Badr, Aboubakr H Abdelmonsef

Open access · goldFull text read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Recent progress in the exploitation of anti-cancer small molecules targeting angiogenesis.Journal of enzyme inhibition and medicinal chemistry · 2025
    Review
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  8. New 1,3-diphenyl-1Heliyon · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. NovelJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Abdelfattah HassanDepartment of Medicinal Chemistry, Faculty of Pharmacy, South Valley University, Qena, Egypt.ORCID 0000-0001-8539-662X
Fawzy A F MubarakDepartment of Chemistry, Faculty of Science, South Valley University, Qena, Egypt.
Ihsan A ShehadiDepartment of Chemistry, College of Sciences, Pure and Applied Chemistry Research Group, University of Sharjah, Sharjah, United Arab Emirates.
Ahmed M MosallamDepartment of Chemistry, Faculty of Science, South Valley University, Qena, Egypt.
Hussain TemairkDepartment of Chemistry, Faculty of Science, South Valley University, Qena, Egypt.
Mohamed BadrDepartment of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt.ORCID 0000-0003-3596-1664
Aboubakr H AbdelmonsefDepartment of Chemistry, Faculty of Science, South Valley University, Qena, Egypt.
South Valley University · EGMenoufia University · EGUniversity of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In this study, we designed 3-substituted quinazoline-2,4(1

Indexed as

Antineoplastic AgentsQuinazolinesAnilidesCell ProliferationDrug DesignDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructureProtein Kinase InhibitorsPyridinesStructure-Activity RelationshipVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2AnilidesAntineoplastic AgentscabozantinibProtein Kinase InhibitorsPyridinesQuinazolinesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2c-Metcolorectal cancerN-acylhydrazonequinazoline-24(1H3H)-dioneVEGFR-2

Identifiers

PMID36919632
PMCPMC10026756
OpenAlexW4324307180

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read202
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.