Evidence map›Paper›PMID 36919600›Full record

ArticleCirculation research2023

Evidence That Binding of Cyclic GMP to the Extracellular Domain of NKA (Sodium-Potassium ATPase) Mediates Natriuresis.

Brandon A Kemp, Nancy L Howell, John J Gildea, Josh D Hinkle, Jeffrey Shabanowitz, Donald F Hunt, Mark R Conaway, Susanna R Keller, Robert M Carey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Brandon A KempDepartment of Medicine, Division of Endocrinology and Metabolism (B.A.K., N.L.H., S.R.K., R.M.C.), University of Virginia, Charlottesville.ORCID 0000-0002-0609-3557
Nancy L HowellDepartment of Medicine, Division of Endocrinology and Metabolism (B.A.K., N.L.H., S.R.K., R.M.C.), University of Virginia, Charlottesville.
John J GildeaDepartment of Pathology (J.J.G.), University of Virginia, Charlottesville.
Josh D HinkleDepartment of Chemistry (J.D.H., J.S., D.F.H.), University of Virginia, Charlottesville.
Jeffrey ShabanowitzDepartment of Chemistry (J.D.H., J.S., D.F.H.), University of Virginia, Charlottesville.ORCID 0000-0001-5750-3539
Donald F HuntDepartment of Chemistry (J.D.H., J.S., D.F.H.), University of Virginia, Charlottesville.ORCID 0000-0003-2815-6368
Mark R ConawayDivision of Translational Research and Applied Statistics, Department of Public Health Sciences (M.R.C.), University of Virginia, Charlottesville.
Susanna R KellerDepartment of Medicine, Division of Endocrinology and Metabolism (B.A.K., N.L.H., S.R.K., R.M.C.), University of Virginia, Charlottesville.
Robert M CareyDepartment of Medicine, Division of Endocrinology and Metabolism (B.A.K., N.L.H., S.R.K., R.M.C.), University of Virginia, Charlottesville.ORCID 0000-0001-7238-7396
University of Virginia · USEngineering Systems (United States) · US

Funding

PROTEIN SEQUENCING BY TANDEM MASS SPECTROMETRYR01GM037537 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HUNT, DONALD F · 1987 to 2023
$17.8M
Renal AT2 Receptors in HypertensionR01HL128189 · NHLBI · UNIVERSITY OF VIRGINIA · PI KELLER, SUSANNA R · 2016 to 2024
$5.0M
Multiscale Modeling of Myelodysplastic SyndromesR01HL128173 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI COREY, SETH JOEL, KIMMEL, MAREK · 2015 to 2019
$3.8M
NHLBI NIH HHS R01 HL128173NHLBI NIH HHS R01 HL128189NIGMS NIH HHS R01 GM037537
6 · The paper itself

Abstract

backgroundExtracellular renal interstitial guanosine cyclic 3',5'-monophosphate (cGMP) inhibits renal proximal tubule (RPT) sodium (Na

methodsUrine Na

resultsRenal interstitial cGMP and raised renal perfusion pressure induced natriuresis and increased phosphorylated Src

conclusionscGMP can bind to NKA and thereby mediate natriuresis.

Indexed as

Cyclic GMPNatriuresisSodium-Potassium-Exchanging ATPaseAdenosine TriphosphatasesAnimalsBiotinBoron CompoundsFemaleOuabainPotassiumRatsRats, Sprague-DawleySodium4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAdenosine TriphosphatasesBiotinBoron CompoundsCyclic GMPOuabainPotassiumSodiumSodium-Potassium-Exchanging ATPaseamino acidsnatriuresisouabainperfusionsodium

Identifiers

PMID36919600
PMCPMC10171454
OpenAlexW4324303456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.