Evidence map›Paper›PMID 36919473›Full record

ArticleNanotoxicology2023

Polyethyleneimine/polyethylene glycol-conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay-

Yoo-Seok Hwang, Daeho So, Moonsup Lee, Jaeho Yoon, Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C Nelson, David A LaVan, Vincent A Hackley and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotoxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Adverse Effect of Metallic Gold and Silver Nanoparticles onNanomaterials (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Yoo-Seok HwangNational Cancer Institute, Frederick, Maryland, USA.
Daeho SoNational Cancer Institute, Frederick, Maryland, USA.
Moonsup LeeNational Cancer Institute, Frederick, Maryland, USA.
Jaeho YoonNational Cancer Institute, Frederick, Maryland, USA.
Vytas ReipaMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Alessandro TonaMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Feng YiMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Bryant C NelsonMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
David A LaVanMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Vincent A HackleyMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
Ira O DaarNational Cancer Institute, Frederick, Maryland, USA.
Tae Joon ChoMaterial Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland, USA.
National Cancer Institute · USNational Institute of Standards and Technology · USMaterial Measurement Laboratory · US

Funding

Signaling Mechanisms of EphrinB1 in Cell Adhesion, Migration and InvasionZIABC010958 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DAAR, IRA · 2009 to 2025
$11.5M
Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National Institute of Standards and Technology recently succeeded in producing remarkably stable polyethyleneimine (PEI)-coated AuNPs (Au-PEI). This improved version of Au-PEI (Au-PEI25kB) has increased the demand for toxicity and teratogenicity information for applications in nanomedicine and nanotoxicology. In vitro assays for Au-PEI25kB in various cell lines showed substantial active cytotoxicity. For advanced toxicity research, the frog embryo teratogenesis assay-

Indexed as

Metal NanoparticlesTeratogenesisAnimalsEmbryo, NonmammalianGoldIminesMammalsPolyethylene GlycolsPolyethyleneiminePolyethylenesTeratogensXenopus laevisGoldIminesPolyethylene Glycolspoly(ethylene imine)PolyethyleneiminePolyethylenesTeratogensFETAXgold nanoparticlesnanoscale controlsnanotoxicologyXenopus laevis

Identifiers

PMID36919473
PMCPMC10471858
OpenAlexW4324306033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.