Evidence map›Paper›PMID 36919195›Full record

ArticleBrain and behavior2023

Error-related brain activity associated with obsessive-compulsive symptoms in youth.

Hannah Becker, Yanni Liu, Gregory L Hanna, Emily Bilek, Stefanie Russman Block, Jillian E Hardee, Mary M Heitzeg, David Pagliaccio, Rachel Marsh, Kate D Fitzgerald

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hannah BeckerDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0001-6944-1208
Yanni LiuDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Gregory L HannaDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Emily BilekDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Stefanie Russman BlockDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Jillian E HardeeDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Mary M HeitzegDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
David PagliaccioNew York State Psychiatric Institute, Columbia University, New York, New York, USA.
Rachel MarshNew York State Psychiatric Institute, Columbia University, New York, New York, USA.
Kate D FitzgeraldNew York State Psychiatric Institute, Columbia University, New York, New York, USA.
University of Michigan · USNew York Psychoanalytic Society and Institute · US

Funding

RISK AND COPING IN CHILDREN OF ALCOHOLICSR01AA007065 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HEITZEG, MARY M · 1987 to 2017
$6.1M
Brain Endophenotypes Modulating Drug Abuse RiskR01DA027261 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZUCKER, ROBERT ALPERT · 2009 to 2013
$3.3M
Sex differences in the neural mechanisms of brief interventions for binge drinkingK01AA024804 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARDEE, JILLIAN ELIZABETH · 2016 to 2020
$830k
NIAAA NIH HHS K01 AA024804NIAAA NIH HHS R01 AA007065NIDA NIH HHS R01 DA027261
6 · The paper itself

Abstract

backgroundSubclinical obsessive-compulsive symptoms (OCS) are common in children, and increase risk for later onset of obsessive-compulsive disorder (OCD). In pediatric patients with OCD, neuroimaging research implicates altered neural mechanisms for error-processing, but whether abnormal brain response occurs with subclinical OCS remains poorly understood.

methodsUsing functional magnetic resonance imaging (fMRI), 113 youth (8-18 years; 45 female) from a community sample were scanned during an error-eliciting Go/No-Go task. OCS were assessed dimensionally using the obsessive-compulsive subscale of the Child Behavior Checklist. The association between OCS scores and error-related brain activity was examined at the whole-brain level.

resultsLower OCS scores associated with stronger response to errors in dorsal anterior cingulate cortex (dACC), caudate, putamen, thalamus, and occipital cortex. Additionally, lower OCS related to higher capacity for inhibitory control, as indexed by greater accuracy on No-Go trials during fMRI scanning. The relationship between lower OCS and better accuracy on No-Go trials was mediated by greater error-related dACC activity.

conclusionsThe inverse relationship between OCS and error-related activity in the dACC and extended cortical-striatal-thalamic circuitry may index an adaptive process by which subclinical OCS are minimized in youth. Further, these results identify an observable pattern of brain activity that tracks with subclinical OCS severity. Understanding the link between neural networks for error processing and the normal to abnormal range of OCS may pave the way for brain-based strategies to identify children who are more likely to develop OCD and enable the targeting of preventive strategies to reduce risk.

Indexed as

Obsessive-Compulsive DisorderAdolescentBrainChildFemaleGyrus CinguliHumansMagnetic Resonance ImagingNeuroimagingcommunity sampledimensional approachdorsal anterior cingulate cortexerror processingobsessive-compulsive symptomsyouth

Identifiers

PMID36919195
PMCPMC10097091
OpenAlexW4324308680

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.