ArticleJournal of diabetes2023
The Association of Retinal age gap with metabolic syndrome and inflammation.
Article in Journal of diabetes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06242535 (Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
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- Fellow-eye retinal age gap and high injection burden over four years in neovascular age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Clinical determinants of retinal age gap estimated from fundus photographs in glaucoma patients.Scientific reports · 2026Observational
- Macula- Versus Disc-Centered Fundus Photography: Performance in Age-Prediction and Disease Associations.Investigative ophthalmology & visual science · 2026Article
- Reduction of glycation stress as a geroscience intervention: protocol for a pilot RCT in postmenopausal women.npj aging · 2026Article
- Modifiable risk factors associated with increased retinal age gap in an Australian population.GeroScience · 2026Article
- A multimodal retinal aging clock for biological age prediction and systemic health assessment via OCT and fundus imaging.Scientific reports · 2026Article
- The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia.Schizophrenia bulletin · 2026Article
- Eye and Systemic Disease Management Changes After Teleophthalmology Screening in Primary Care: Retrospective Cross-Sectional Pilot Study of 200 Consecutive Patients.JMIR formative research · 2025Article
- Fundus Refraction Offset as an Individualized Myopia Biomarker.JAMA ophthalmology · 2025Article
- A cross population study of retinal aging biomarkers with longitudinal pre-training and label distribution learning.NPJ digital medicine · 2025Article
- Article
- Evaluating the reproducibility of a deep learning algorithm for the prediction of retinal age.GeroScience · 2025Article
- Sleep onset time as a mediator in the association between screen exposure and aging: a cross-sectional study.GeroScience · 2025Article
- Artificial intelligence-enhanced retinal imaging as a biomarker for systemic diseases.Theranostics · 2025Review
- Advances in ocular aging: combining deep learning, imaging, and liquid biopsy biomarkers.Frontiers in medicine · 2025Review
- A Novel Foundation Model-Based Framework for Multimodal Retinal Age Prediction.IEEE journal of translational engineering in health and medicine · 2025Article
- Comparative analysis of three BMI cutoffs for five metabolic abnormalities in the population of Western Guangdong, China.Frontiers in nutrition · 2025Article
- Foundation model-driven distributed learning for enhanced retinal age prediction.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Estimating biological age from retinal imaging: a scoping review.BMJ open ophthalmology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundMetabolic syndrome (MetS) is a clustering of cardiometabolic components, posing tremendous burdens in the aging society. Retinal age gap has been proposed as a robust biomarker associated with mortality and Parkinson's disease. Although MetS and chronic inflammation could accelerate the aging process and increase the risk of mortality, the association of the retinal age gap with MetS and inflammation has not been examined yet.
methodsRetinal age gap (retina-predicted age minus chronological age) was calculated using a deep learning model. MetS was defined as the presence of three or more of the following: central obesity, hypertension, dyslipidemia, hypertriglyceridemia, and hyperglycemia. Inflammation index was defined as a high-sensitivity C-reactive protein level above 3.0 mg/L. Logistic regression models were used to examine the associations of retinal age gaps with MetS and inflammation.
resultsWe found that retinal age gap was significantly associated with MetS and inflammation. Specifically, compared to participants with retinal age gaps in the lowest quartile, the risk of MetS was significantly increased by 10% and 14% for participants with retinal age gaps in the third and fourth quartile (odds ratio [OR]:1.10; 95% confidence interval [CI], 1.01,1.21;, p = .030; OR: 1.14, 95% CI, 1.03,1.26; p = .012, respectively). Similar trends were identified for the risk of inflammation and combined MetS and inflammation.
conclusionWe found that retinal age gaps were significantly associated with MetS as well as inflammation. Given the noninvasive and cost-effective nature and the efficacy of the retinal age gap, it has great potential to be used as a screening tool for MetS in large populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.