Evidence map›Paper›PMID 36919188›Full record

ArticleJournal of veterinary internal medicine2023

Association of folate concentrations with clinical signs and laboratory markers of chronic enteropathy in dogs.

Tarini V Ullal, Stanley L Marks, Sara N Huebner, Sandra L Taylor, Courtney D Shelley

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tarini V UllalDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID https://orcid.org/0000-0002-8728-3706
Stanley L MarksDepartment of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, USA.ORCID https://orcid.org/0000-0001-7991-702X
Sara N HuebnerSchool of Veterinary Medicine, University of California Davis, Davis, California, USA.
Sandra L TaylorDivision of Biostatistics, School of Medicine, University of California, Sacramento, California, USA.ORCID https://orcid.org/0000-0001-7811-812X
Courtney D ShelleyDivision of Biostatistics, School of Medicine, University of California, Sacramento, California, USA.
University of California, Davis · USCalifornia Department of Education · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum folate is considered a biomarker of chronic enteropathy (CE) in dogs, but few studies have examined associations with markers of CE. HYPOTHESIS/

objectivesTo evaluate serum folate concentrations in dogs with and without CE and associations with sample hemolysis and selected markers of CE. We hypothesized that hypofolatemia would be more common in dogs with CE and associated with hypocobalaminemia, higher CIBDAI, and hypoalbuminemia. ANIMALS: Six hundred seventy-three dogs with available serum folate measurements performed at an academic veterinary hospital between January 2016 and December 2019.

methodsMedical records were retrospectively reviewed to categorize cases as CE or non-CE and record clinical details and laboratory markers. Relationships between serum folate, cobalamin, and CE variables were assessed using chi-square, Kruskal-Wallis, or Spearman's correlation tests.

resultsOf the 673 dogs, 99 CE were compared to 95 non-CE. In the overall cohort, serum folate concentration did not correlate with sample hemolysis (P = .75). In the CE subset, serum folate and cobalamin concentrations were positively associated (rho = 0.34, FDR = 0.02). However, serum folate concentrations (median [25th, 75th percentiles]) were higher (CE: 12.1 (8.9, 16.1), non-CE: 10.4 (7.2, 15.5); P = .04) and cobalamin concentrations were lower (CE: 343 (240, 597), non-CE: 550 (329, 749); P = .001) in the CE vs non-CE group. Serum folate was not associated with markers of CE, but serum cobalamin was associated with albumin (P = .04) and cholesterol (P = .03). CONCLUSIONS AND CLINICAL IMPORTANCE: Hypofolatemia is an inferior biomarker of CE compared to hypocobalaminemia.

Indexed as

Dog DiseasesInflammatory Bowel DiseasesVitamin B 12 DeficiencyAnimalsBiomarkersDogsFolic AcidHemolysisRetrospective StudiesVitamin B 12BiomarkersFolic AcidVitamin B 12CIBDAIfolic acidfood-responsive enteropathyimmunosuppressant-responsive enteropathyinflammatory bowel disease

Identifiers

PMID36919188
PMCPMC10061186
OpenAlexW4324311524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.