Evidence map›Paper›PMID 36918976›Full record

ArticleAlzheimer's research & therapy2023

Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH

Li Chen, Lei Xiong, Lingling Yao, Jinxiu Pan, Emily Arzola, Xiaojuan Zhu, Lin Mei, Wen-Cheng Xiong

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Li Chen *Department of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Lei Xiong *Department of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Lingling YaoDepartment of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Jinxiu PanDepartment of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Emily ArzolaDepartment of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Xiaojuan ZhuInstitute of Cytology and Genetics, Northeast Normal University, Changchun, Jilin, China.
Lin MeiDepartment of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA.
Wen-Cheng XiongDepartment of Neurosciences, School of Medicine, Case Western Reserve University, 2210 Circle Dr, Cleveland, OH, 44106, USA. Wen-Cheng.Xiong@case.edu.
Case Western Reserve University · USNortheast Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) and osteoporosis are two distinct diseases but often occur in the same patient. Their relationship remains poorly understood. Studies using Tg2576 AD animal model demonstrate bone deficits, which precede the brain phenotypes by several months, arguing for the independence of bone deficits on brain degeneration and raising a question if the bone deficits contribute to the AD development. To address this question, we investigated the effects of PTH

methods5XFAD mice, an early onset β-amyloid (Aβ)-based AD mouse model, were treated with PTH

resultsA reduced trabecular, but not cortical, bone mass, accompanied with a decrease in bone formation and an increase in bone resorption, was detected in 5XFAD mice at age of 5/6-month old (MO). Upon PTH

conclusionsThese results suggest that PTH

Indexed as

Alzheimer DiseaseEncephalitisAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBrainCytokinesDisease Models, AnimalMiceMice, Inbred C57BLMice, TransgenicParathyroid HormoneAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCytokinesParathyroid HormoneAlzheimer’s diseaseAstrocytesAβNeuroinflammationPTH

Identifiers

PMID36918976
PMCPMC10012528
OpenAlexW4324142519

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read91
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.