ArticleBiotechnology for biofuels and bioproducts2023
Integrated metabolic and transcriptional analysis reveals the role of carotenoid cleavage dioxygenase 4 (IbCCD4) in carotenoid accumulation in sweetpotato tuberous roots.
Article in Biotechnology for biofuels and bioproducts, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Transcriptomic and Targeted Carotenoid Metabolomic Dissection of Pod Color Difference Between Wild Type and an EMS-Induced StableInternational journal of molecular sciences · 2026Article
- Comparative Metabolomic Analysis Reveals the Varied Accumulations of Functional Nutrients in Differentially Pigmented Mung Bean Seeds.Foods (Basel, Switzerland) · 2026Article
- Uncoupling the nexus between yield and carotenoid levels in sweet potato: development of improved cultivars and identification of key improvement genes.BMC plant biology · 2026Article
- Natural allelic variation of basic helix-loop-helix transcription factor 25 regulates carotenoid biosynthesis in sweet potato.Plant biotechnology journal · 2025Article
- Transcriptomic and targeted metabolomic insights into carotenoid-mediated color formation in sorghum grains.Frontiers in plant science · 2025Article
- Transcriptomic Analysis Reveals the Mechanism of Color Formation in the Peel of an Evergreen Pomegranate Cultivar 'Danruo No.1' During Fruit Development.Plants (Basel, Switzerland) · 2024Article
- Identification and Characterization of theInternational journal of molecular sciences · 2024Article
- Impact of steam cooking on the chemical profile of table-stock sweetpotatoes with different carotenoids content.Food chemistry: X · 2024Article
- A comprehensive overview of omics-based approaches to enhance biotic and abiotic stress tolerance in sweet potato.Horticulture research · 2024Article
- The same boat, different storm: stress volatile emissions in response to biotrophic fungal infections in primary and alternate hosts.Plant signaling & behavior · 2023Article
- Comparison of Bioactive Compounds and Antioxidant Activities in Differentially PigmentedMolecules (Basel, Switzerland) · 2023Article
- Characterization ofPlants (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundPlant carotenoids are essential for human health, having wide uses in dietary supplements, food colorants, animal feed additives, and cosmetics. With the increasing demand for natural carotenoids, plant carotenoids have gained great interest in both academic and industry research worldwide. Orange-fleshed sweetpotato (Ipomoea batatas) enriched with carotenoids is an ideal feedstock for producing natural carotenoids. However, limited information is available regarding the molecular mechanism responsible for carotenoid metabolism in sweetpotato tuberous roots.
resultsIn this study, metabolic profiling of carotenoids and gene expression analysis were conducted at six tuberous root developmental stages of three sweetpotato varieties with different flesh colors. The correlations between the expression of carotenoid metabolic genes and carotenoid levels suggested that the carotenoid cleavage dioxygenase 4 (IbCCD4) and 9-cis-epoxycarotenoid cleavage dioxygenases 3 (IbNCED3) play important roles in the regulation of carotenoid contents in sweetpotato. Transgenic experiments confirmed that the total carotenoid content decreased in the tuberous roots of IbCCD4-overexpressing sweetpotato. In addition, IbCCD4 may be regulated by two stress-related transcription factors, IbWRKY20 and IbCBF2, implying that the carotenoid accumulation in sweeetpotato is possibly fine-tuned in responses to stress signals.
conclusionsA set of key genes were revealed to be responsible for carotenoid accumulation in sweetpotato, with IbCCD4 acts as a crucial player. Our findings provided new insights into carotenoid metabolism in sweetpotato tuberous roots and insinuated IbCCD4 to be a target gene in the development of new sweetpotato varieties with high carotenoid production.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.