Evidence map›Paper›PMID 36918830›Full record

ArticleBMC ophthalmology2023

Volume-accumulated reflectivity of the outer retina (integral) on spectral domain optical coherence tomography as a predictor of cone cell density: a pilot study.

Wenting Li, Wenwen Chen, Xiyue Zhou, Tingting Jiang, Juan Zhang, Min Wang, Jihong Wu, Junxiang Gu, Qing Chang

Open access · goldFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wenting Li *Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Wenwen Chen *Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Xiyue ZhouDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Tingting JiangDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Juan ZhangDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Min WangDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Jihong WuDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China.
Junxiang GuDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China. junxiang_gu@icloud.com.
Qing ChangDepartment of Ophthalmology, Eye and ENT Hospital of Fudan University, Fudan University, Xuhui District, 83 Fenyang Rd, Shanghai, China. qngchang@aliyun.com.
Fudan University · CNEye & ENT Hospital of Fudan University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

National Natural Science Foundation of China 81870670Shanghai Hospital Development Center SHDC2020CR5014-003Shanghai Science and Technology Development Foundation 18411965100
6 · The paper itself

Abstract

backgroundThe study aims to investigate the relationship between the volume-accumulated reflectivity (termed "integral") on spectral domain optical coherence tomography (SD-OCT) and cone density on adaptive optics (AO) imaging.

methodsIn this cross-sectional study, both eyes of 32 healthy subjects and 5 patients with inherited retinal diseases (IRD) were studied. The parameter, integral, was defined as the volume-accumulated reflectivity values in a selected region on OCT images; integrals of the ellipsoid zone (EZ) and interdigitation zone (IZ) were measured at 2°, 3°, 4°, 5°and 6° eccentricity along the four meridians on fovea-centered OCT B-scans. Cone density in the same region was measured using a flood illumination adaptive optics camera RTX1.

resultsIntegrals of EZ, IZ and cone density shared similar distribution patterns. Integral of the IZ was better correlated with cone density in both healthy people (r = 0.968, p < 0.001) and those with IRD (r = 0.823, p < 0.001) than direct measurements of reflectivity on OCT images. A strong correlation was found between best corrected visual acuity (BCVA) and cone density at 2° eccentricity (r = -0.857, p = 0.002). BCVA was also correlated with the integral of the IZ at the foveola (r = -0.746, p = 0.013) and fovea (r = -0.822, p = 0.004).

conclusionsThe new parameter "integral" of the photoreceptor outer segment measured from SD-OCT was noted to correlate with cone density and visual function in this pilot study.

Indexed as

Retinal Cone Photoreceptor CellsRetinal DiseasesTomography, Optical CoherenceCell CountCross-Sectional StudiesHumansPilot ProjectsRetinaAdaptive opticsEllipsoid zoneInherited retinal diseasesInterdigitation zoneSpectral domain optical coherence tomography

Identifiers

PMID36918830
PMCPMC10012552
OpenAlexW4324149547

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.