Evidence map›Paper›PMID 36918808›Full record

Trial reportBMC cardiovascular disorders2023

Quantitative flow ratio vs. angiography-only guided PCI in STEMI patients: one-year cardiovascular outcomes.

Mindaugas Barauskas, Greta Žiubrytė, Nojus Jodka, Ramūnas Unikas

Erratum issuedOpen access · goldFull text readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Guideline
  5. Trial
  6. Article
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  8. Review
  9. The association between OInternational journal of cardiology. Heart & vasculature · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mindaugas BarauskasDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania. mindaugas.barauskas@lsmu.lt.
Greta ŽiubrytėDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Nojus JodkaDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Ramūnas UnikasDepartment of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lithuanian University of Health Sciences · LTHospital of Lithuanian University of Health Sciences Kaunas Clinics · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronary physiology-guided PCIs are recommended worldwide. However, invasive coronary physiology methods prolong the procedure, create additional risks for the patients, and prolong the fluoroscopy time for an interventional cardiologist. Otherwise, there is a noninvasive coronary physiology evaluation method, QFR, that can be safely used even in STEMI patients.

methodsA total of 198 patients admitted with STEMI and at least one intermediate (35-75%) diameter stenosis other than the culprit artery between July 2020 and June 2021 were prospectively included in this single-center study. All patients were randomized into one of two groups (1 - QFR-guided PCI; 2 - visual-estimation-only guided PCI). A 12-month follow-up with echocardiography, exercise stress test, and quality of life evaluation was performed in all included patients. For the QOF evaluation, the Seattle Angina Score Questionnaire was chosen. Statistical analysis was performed using the Kolmogorov-Smirnov test, Student's t-test, Mann-Whitney U test, Pearson's chi-squared test and Kaplan-Meier estimator.

resultsNinety-eight (49.5%) patients were randomized to the first group, and 100 (50.5%) patients were included in the second group. Statistically, significantly more patients had a medical history of dyslipidemia (98 vs. 91, p = 0.002) and slightly better left ventricular ejection fraction (42.21 ± 7.88 vs. 39.45 ± 9.62, p = 0.045) in the QFR group. Six fewer patients required non-culprit artery revascularization within the 12-month FU in the QFR group (1.02% vs. 6%, p = 0.047). Survival analysis proved that patients in the Angio group had a more than 6-fold greater risk for death within a 12-month period after MI (OR 6.23, 95% CI 2.20-17.87, p = 0.006), with the highest mortality risk within the first two months after initial treatment.

conclusionUsing QFR in non-culprit lesions in patients with ST-elevation myocardial infarction reduces mortality and revascularization at the 12-month follow-up and improves the quality of life of the patient.

trial registrationThe study was approved by the Regional Bioethical Committee and conducted under the principles of the Helsinki Declaration and local laws and regulations.

Indexed as

Coronary Artery DiseaseFractional Flow Reserve, MyocardialPercutaneous Coronary InterventionST Elevation Myocardial InfarctionCoronary AngiographyHumansQuality of LifeStroke VolumeTreatment OutcomeVentricular Function, LeftCoronary physiology evaluation in STEMI.Physiology-guided PCIQFR 12-month follow-upQFR-guided PCIQFR in STEMIQuantitative flow ratio

Identifiers

PMID36918808
PMCPMC10015917
OpenAlexW4324193920

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read29
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.