ArticleBMC neurology2023
The association between malnutrition status and hemorrhagic transformation in patients with acute ischemic stroke receiving intravenous thrombolysis.
Article in BMC neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Impact of coexisting obesity and malnutrition on the clinical outcomes of acute ischemic stroke patients treated with intravenous thrombolysis: a cohort-based study.Frontiers in nutrition · 2026Article
- Analysis of nutritional status and functional recovery outcomes in stroke patients under nursing care.Frontiers in nutrition · 2026Article
- Prognostic value of albumin-based malnutritional indices on short-term outcome in acute ischemic stroke patients undergoing reperfusion therapy.Frontiers in nutrition · 2025Article
- Objective nutritional indices as an independent predictor of functional outcome after endovascular therapy for acute ischemic stroke: a cohort study in a Chinese population.Frontiers in nutrition · 2025Article
- Study of Biochemical Predictors of Early Neurological Deterioration in Ischemic Stroke in a Tertiary Care Hospital.Cureus · 2024Article
- Article
- Predictive Value of Epicardial Adipose Tissue for Hemorrhagic Transformation and Functional Outcomes in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis Therapy.Journal of inflammation research · 2024Article
- Association between Malnutrition and Migraine Risk Assessed Using Objective Nutritional Indices.Nutrients · 2023Article
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7 authors.
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Abstract
objectivesWe evaluated the impact of malnutrition as estimated by the controlling nutritional status (CONUT) score and prognostic nutritional index (PNI) on hemorrhagic transformation (HT) and stroke outcomes after intravenous thrombolysis (IVT). MATERIALS AND
methodsUsing a multicenter registry database, we enrolled 808 patients with acute ischemic stroke who received IVT between August 2013 and May 2021. We defined malnutrition as a CONUT score ≥ 2 and low PNI. The primary outcome measure was the occurrence of symptomatic HT contributing to early neurologic deterioration (END-SHT) after IVT. Multivariable analysis was performed to analyze the association between CONUT score, PNI, and END-SHT after IVT.
resultsThe rate of END-SHT was higher with increasing CONUT scores and PNI values. In the multivariable analysis, CONUT score ≥ 5 and low PNI were significantly associated with END-SHT (odds ratio [95% confidence interval], CONUT score ≥ 5: 12.23 [2.41-62.07], p = 0.003; low PNI: 4.98 [1.76-14.09], p = 0.003). The receiver operating characteristic curve showed that both the CONUT score and PNI had good predictive ability. The cutoff values for CONUT and PNI were 5 and 42.3, respectively, for END-SHT.
conclusionMalnutrition, as denoted by a higher CONUT score and lower PNI, was associated with END-SHT. The joint application of both nutritional markers could be useful in predicting END-SHT after IVT.
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