ArticleNature cell biology2023
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.
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Article in Nature cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Biological Rhythms in Coronavirus Pneumonia Pathogenesis.Journal of biological rhythms · 2026Article
- Delayed antiviral immune response in alveolar type 2 cells increases susceptibility to influenza virus in alveoli.Chinese medical journal · 2026Article
- Organoids: From Bench to Bedside Applications.MedComm · 2026Review
- Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infection in Cthrc1-positive pulmonary fibroblasts derived from the Nile grass rat.Scientific reports · 2026Article
- SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition.Journal of molecular and cellular cardiology plus · 2026Article
- Molecular mechanism of resistance to lonafarnib conferred by mutations in the cysteine-rich region of respiratory syncytial virus fusion glycoprotein and discovery of a lonafarnib-derived antiviral PROTAC.Journal of virology · 2026Article
- Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections.Frontiers in pharmacology · 2026Review
- Single-cell sequencing and organoids: applications in organ development and disease.Molecular biomedicine · 2025Review
- Organoid Models to Study Human Infectious Diseases.Cell proliferation · 2025Review
- Organoids: physiologically relevantJournal of virology · 2025Review
- Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders.Cell death discovery · 2025Review
- Identification and targeting of regulators of SARS-CoV-2-host interactions in the airway epithelium.Science advances · 2025Article
- An evolutionarily conserved constellation of functional cis-elements programs the virus-responsive fate of the human (epi)genome.Nucleic acids research · 2025Article
- Hypoosmotic stress shifts transcription of circadian genes.Biophysical journal · 2025Article
- SCovid v2.0: a comprehensive resource to decipher the molecular characteristics across tissues in COVID-19 and other human coronaviruses.Microbiology spectrum · 2025Article
- Review
- Swimming exercise reverses transcriptomic changes in aging mouse lens.BMC medical genomics · 2024Article
- Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.Cell metabolism · 2023Article
- Uncoupled redox stress: how a temporal misalignment of redox-regulated processes and circadian rhythmicity exacerbates the stressed state.Open biology · 2023Review
- Lipid compartments and lipid metabolism as therapeutic targets against coronavirus.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Xuming Tang *Department of Surgery, Weill Cornell Medicine, New York, NY, USA.
Dongxiang Xue *Department of Surgery, Weill Cornell Medicine, New York, NY, USA.
Tuo Zhang *Genomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5396-918X
Benjamin E Nilsson-Payant *Department of Microbiology, New York University, New York, NY, USA.
Lucia Carrau *Department of Microbiology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0260-2841
Xiaohua DuanDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Miriam GordilloDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Adrian Y TanGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Yunping QiuStable Isotope and Metabolomics Core Facility, The Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Jenny XiangGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Robert E SchwartzDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-5417-5995
Benjamin R tenOeverDepartment of Microbiology, New York University, New York, NY, USA.ORCID http://orcid.org/0000-0003-0324-3078
Todd EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7148-9849
Shuibing ChenDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA. shc2034@med.cornell.edu.ORCID http://orcid.org/0000-0002-6294-5187
Cornell University · USNew York University · USAlbert Einstein College of Medicine · USCenter for Experimental and Clinical Infection Research · DE
Funding
Genetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0MDetermining the Intrinsic and Environmental Signal Contributing to Early T1D ProgressionU01DK127777 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, PARKER, STEPHEN CJ · 2020 to 2023
$3.0MOptimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6MMetallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and SurvivalR01DK119667 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING · 2019 to 2022
$2.5MModeling Hepatoblastoma using pluripotent stem cell derived hepatocyte-like cellsR01CA234614 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2019 to 2023
$1.9MDecode the Impact of SARS-CoV-2 on Human PancreasR01DK130454 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, SHUIBING, LIM, JEAN KYOU · 2021 to 2023
$1.3MIdentification of Hepatitis B Virus permissiveness factorsR03DK117252 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2018 to 2019
$254kGates Foundation INV-037420NCI NIH HHS R01 CA234614NIAID NIH HHS R01 AI107301NIDDK NIH HHS R01 DK119667NIDDK NIH HHS R01 DK121072NIDDK NIH HHS R01 DK130454NIDDK NIH HHS R03 DK117252NIDDK NIH HHS U01 DK127777
Abstract
COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug screens
Indexed as
Circadian Rhythm Signaling Peptides and ProteinsCOVID-19HumansLungOrganoidsRNASARS-CoV-2CIART protein, humanCircadian Rhythm Signaling Peptides and ProteinsRNA
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.