Evidence map›Paper›PMID 36918596›Full record

ArticleScientific reports2023

Antiretroviral therapy regimen modification rates and associated factors in a cohort of HIV/AIDS patients in Asmara, Eritrea: a 16-year retrospective analysis.

Samuel Tekle Mengistu, Arsema Yohannes, Hermon Issaias, Mical Mesfn, Simon Zerufael, Aman Dirar, Habtemichael M Teklemariam, Ghirmary Ghebrekidane Ghebremeskel, Oliver Okoth Achila, Saleem Basha

Open access · goldFull text read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Samuel Tekle MengistuNakfa Hospital, Ministry of Health Northern Red Sea Branch, Nakfa, Eritrea. teklesam7@gmail.com.ORCID 0000-0002-2817-1421
Arsema YohannesOrotta College of Medicine and Health Sciences, Asmara, Eritrea.
Hermon IssaiasOrotta College of Medicine and Health Sciences, Asmara, Eritrea.
Mical MesfnOrotta College of Medicine and Health Sciences, Asmara, Eritrea.
Simon ZerufaelOrotta College of Medicine and Health Sciences, Asmara, Eritrea.
Aman DirarEritrean National Institute of Higher Education and Research, Mai-Nefhi College of Sciences, Mai-Nefhi, Eritrea.ORCID 0000-0002-2668-3677
Habtemichael M TeklemariamTeseney Hospital, Ministry of Health Gash-Barka Branch, Teseney, Eritrea.ORCID 0000-0003-2961-8165
Ghirmary Ghebrekidane GhebremeskelNakfa Hospital, Ministry of Health Northern Red Sea Branch, Nakfa, Eritrea.ORCID 0000-0002-0275-2279
Oliver Okoth AchilaUnit of Clinical Laboratory Sciences, Orotta College of Medicine and Health Sciences, Asmara, Eritrea.ORCID 0000-0001-8013-0785
Saleem BashaUnit of Allied Sciences, Orotta College of Medicine and Health Sciences, Asmara, Eritrea.
University of Asmara · ERMinisterio de Salud · SV

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined antiretroviral therapy (cART) durability and time to modification are important quality indicators in HIV/AIDs treatment programs. This analysis describes the incidence, patterns, and factors associated with cART modifications in HIV patients enrolled in four treatment centers in Asmara, Eritrea from 2005 to 2021. Retrospective cohort study combining data from 5020 [males, 1943 (38.7%) vs. females, 3077 (61.3%)] patients were utilized. Data on multiple demographic and clinical variables were abstracted from patient's charts and cART program registry. Independent predictors of modification and time to specified events were evaluated using a multi-variable Cox-proportional hazards model and Kaplan-Meier analysis. The median (±IQR) age, CD4

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsHIV InfectionsAdultEritreaFemaleHumansMaleMiddle AgedProportional Hazards ModelsRetrospective StudiesAnti-HIV Agents

Identifiers

PMID36918596
PMCPMC10015006
OpenAlexW4324150551

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read151
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.