Evidence map›Paper›PMID 36918579›Full record

ArticleSchizophrenia (Heidelberg, Germany)2023

Connectivity alterations of mesostriatal pathways in first episode psychosis.

Nicholas Mark Edward Alexander Hayward, Ana María Triana, Jonatan M Panula, Tuula Kieseppä, Jaana Suvisaari, Tuukka T Raij

Open access · diamondFull text read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Microstructural Alterations of the Cerebellum-Ventral Tegmental Area Pathways in First-Episode Psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Nicholas Mark Edward Alexander HaywardDepartment of Neuroscience and Biomedical Engineering, Aalto University, P.O. Box 11000, Espoo, FI-00076, Finland.
Ana María TrianaDepartment of Computer Science, Aalto University, P.O. Box 15400, Espoo, FI-00076, Finland.
Jonatan M PanulaDepartment of Neuroscience and Biomedical Engineering, Aalto University, P.O. Box 11000, Espoo, FI-00076, Finland.
Tuula KieseppäDepartment of Clients and Services, Unit of Services, Ministry of Social Affairs and Health, P.O. Box 33, Helsinki, FI-00023, Finland.
Jaana SuvisaariFinnish Institute for Health and Welfare, Mental Health Team, P.O. Box 30, Helsinki, FI-00271, Finland.ORCID http://orcid.org/0000-0001-7167-0990
Tuukka T RaijDepartment of Neuroscience and Biomedical Engineering, Aalto University, P.O. Box 11000, Espoo, FI-00076, Finland. Tuukka.raij@hus.fi.
Aalto University · FIFinnish Institute for Health and Welfare · FIMinistry of Social Affairs and Health · FIUniversity of Helsinki · FI

Funding

Academy of Finland (Suomen Akatemia) #278171Academy of Finland (Suomen Akatemia) 278171Academy of Finland (Suomen Akatemia) #315861Academy of Finland (Suomen Akatemia) #323035Academy of Finland (Suomen Akatemia) 323035EC | Seventh Framework Programme (EC Seventh Framework Programm) #602478
6 · The paper itself

Abstract

background and hypothesisPathogenic understanding of the psychotic disorders converges on regulation of dopaminergic signaling in mesostriatocortical pathways. Functional connectivity of the mesostriatal pathways may inform us of the neuronal networks involved. STUDY

designThis longitudinal study of first episode psychosis (FEP) (49 patients, 43 controls) employed seed-based functional connectivity analyses of fMRI data collected during a naturalistic movie stimulus. STUDY

resultsWe identified hypoconnectivity of the dorsal striatum with the midbrain, associated with antipsychotic medication dose in FEP, in comparison with the healthy control group. The midbrain regions that showed hypoconnectivity with the dorsal striatum also showed hypoconnectivity with cerebellar regions suggested to be involved in regulation of the mesostriatocortical dopaminergic pathways. None of the baseline hypoconnectivity detected was seen at follow-up.

conclusionsThese findings extend earlier resting state findings on mesostriatal connectivity in psychotic disorders and highlight the potential for cerebellar regulation of the mesostriatocortical pathways as a target of treatment trials.

Identifiers

PMID36918579
PMCPMC10014938
OpenAlexW4324142509

What OpenQuestion holds

Textfull text, public
LicenceCC BY
reference markers read1
measurements read10
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.