ArticleNature communications2023
Evolutionary differentiation of androgen receptor is responsible for sexual characteristic development in a teleost fish.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- 5α-Reductase underscores the development of pectoral fin breeding tubercles in zebrafish.Communications biology · 2026Article
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- Resistance of AdultIntegrative organismal biology (Oxford, England) · 2026Article
- BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells.Environmental epigenetics · 2026Article
- Population Variation in Steroid Hormone-Related Gene Expression and Sexually Dimorphic Communication in the Electric Fish Apteronotus albifrons.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2025Article
- The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens.Nucleic acids research · 2025Article
- Disrupting Amh and androgen signaling reveals their distinct roles in zebrafish gonadal differentiation and gametogenesis.Communications biology · 2025Article
- Evolution of Size-Fecundity Relationship in Medaka Fish From Different Latitudes.Molecular ecology · 2024Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.Journal of neuroendocrinology · 2024Article
- Steroid hormone-deprived sex reversal in cyp11a1 mutant XX tilapia experiences an ovary-like stage at molecular level.Communications biology · 2024Article
- Differential expression of steroid-related genes across electrosensory brain regions in two sexually dimorphic species of electric knifefish.General and comparative endocrinology · 2024Review
- The decision of male medaka to mate or fight depends on two complementary androgen signaling pathways.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Loss of Fshr Prevents Testicular Maturation in Atlantic Salmon (Salmo salar L.).Endocrinology · 2024Article
- Expression of novel androgen receptors in three GnRH neuron subtypes in the cichlid brain.bioRxiv : the preprint server for biology · 2024Article
- DNA Methylation Profiling of Ovarian Tissue of Climbing Perch (Anabas testudienus) in Response to Monocrotophos Exposure.Marine biotechnology (New York, N.Y.) · 2023Article
- Evolution of androgen receptors contributes to species variation in androgenic regulation of communication signals in electric fishes.Molecular and cellular endocrinology · 2023Article
- Elacestrant: a new FDA-approved SERD for the treatment of breast cancer.Medical oncology (Northwood, London, England) · 2023Review
- Mutation of brain aromatase disrupts spawning behavior and reproductive health in female zebrafish.Frontiers in endocrinology · 2023Article
- Control of social status by sex steroids: insights from teleost fishes.Molecular psychology : brain, behavior, and society · 2023Article
- Computer-Aided Sperm Analysis Protocol for Evaluating Sperm Motility in Japanese Medaka.Development, growth & differentiationArticle
Corrections and comments
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Authors and funding
22 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teleost fishes exhibit complex sexual characteristics in response to androgens, such as fin enlargement and courtship display. However, the molecular mechanisms underlying their evolutionary acquisition remain largely unknown. To address this question, we analyse medaka (Oryzias latipes) mutants deficient in teleost-specific androgen receptor ohnologs (ara and arb). We discovered that neither ar ohnolog was required for spermatogenesis, whilst they appear to be functionally redundant for the courtship display in males. However, both were required for reproductive success: ara for tooth enlargement and the reproductive behaviour eliciting female receptivity, arb for male-specific fin morphogenesis and sexual motivation. We further showed that differences between the two ar ohnologs in their transcription, cellular localisation of their encoded proteins, and their downstream genetic programmes could be responsible for the phenotypic diversity between the ara and arb mutants. These findings suggest that the ar ohnologs have diverged in two ways: first, through the loss of their roles in spermatogenesis and second, through gene duplication followed by functional differentiation that has likely resolved the pleiotropic roles derived from their ancestral gene. Thus, our results provide insights into how genome duplication impacts the massive diversification of sexual characteristics in the teleost lineage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.