ArticleScientific reports2023
Screening of potential immune-related genes expressed during sepsis using gene sequencing technology.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Integrated bioinformatics analysis of molecular signatures and therapeutic targets in early sepsis.Frontiers in cellular and infection microbiology · 2026Article
- The ferroptosis-related gene MAFG screened by machine learning is associated with the diagnosis and prognosis of sepsis.Clinical and experimental medicine · 2025Article
- Evaluating the InSignia IFI27 expression assay for detecting viral respiratory infection compared to a traditional gene normalisation assay.Scientific reports · 2025Article
- Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model.Journal of neuroinflammation · 2025Article
- Structural Variation Analysis in the samd3/elf3 Intergenic Region of the Barred knifejaw (Oplegnathus fasciatus) and the Development of Molecular Marker for Efficient Sex Identification.Marine biotechnology (New York, N.Y.) · 2025Article
- Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment.BMC medical genomics · 2025Observational
- RAB13 regulates macrophage polarization in sepsis.Scientific reports · 2024Article
- Identification of sepsis-associated mitochondrial genes through RNA and single-cell sequencing approaches.BMC medical genomics · 2024Article
- Article
- T cell dysfunction in elderly ARDS patients based on miRNA and mRNA integration analysis.Frontiers in immunology · 2024Observational
- Peripheral immune cell death in sepsis based on bulk RNA and single-cell RNA sequencing.Heliyon · 2023Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To screen potential pivotal targets in sepsis through peripheral blood. Septic patients (n = 23) and healthy volunteers (n = 10) were enrolled according to SEPSIS 3.0. Peripheral blood was collected within 24 h of enrollment, RNA-seq was performed on the peripheral blood. The sequencing data was screened for DEGs (p < 0.01; logFC ≥ 2). PPI, WGCNA and survival curve analysis were used to identify potential targets. Then, 5 PBMC samples were conducted by single-cell sequencing for cell lineage location. Finally, mouse sepsis model and clinic samples were performed to verify the targets gene using RNA-seq and RT-PCR, respectively. Compared to the control group, 1007 DEGs were found in septic group. BCL9L, BCL11B, CD247, CD96, MAFG and SAMD3 were in the core of network. These six genes correlated to the survival rate of septic patients and they were mainly expressed in T cells, except that MAFG was located in monocyte cell. The expression levels of six key genes were confirmed by animal and clinical samples. BCL9L, BCL11B, CD247, CD96 and SAMD3 were decreased in sepsis and mainly expressed in the T cell; while MAFG increased in sepsis and localizes to monocytes. These genes may be therapeutic targets for sepsis.
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