Evidence map›Paper›PMID 36918533›Full record

ArticleNature communications2023

Noninvasive electromyometrial imaging of human uterine maturation during term labor.

Hui Wang, Zichao Wen, Wenjie Wu, Zhexian Sun, Zulfia Kisrieva-Ware, Yiqi Lin, Sicheng Wang, Hansong Gao, Haonan Xu, Peinan Zhao and 6 more

Open access · goldFull text read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. An update on pacemaking in the myometrium.The Journal of physiology · 2026
    Review
  4. Review
  5. Review
  6. Observational
  7. Article
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Hui Wang *Department of Physics, Washington University, St. Louis, MO, 63130, USA.ORCID 0000-0002-8580-6235
Zichao Wen *Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0002-1169-3768
Wenjie WuCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0002-1317-104X
Zhexian SunCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0003-1225-182X
Zulfia Kisrieva-WareCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.
Yiqi LinCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0001-7650-1790
Sicheng WangCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0002-6423-7029
Hansong GaoCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.ORCID 0000-0002-1599-9932
Haonan XuCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA.
Peinan ZhaoDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Qing WangMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
George A MaconesDepartment of Women's Health, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA.
Alan L SchwartzDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Phillip CuculichDepartment of Cardiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Alison G CahillDepartment of Women's Health, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA.
Yong WangCenter for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, MO, 63130, USA. wangyong@wustl.edu.ORCID 0000-0003-2507-8333
Washington University in St. Louis · USThe University of Texas at Austin · USMallinckrodt (United States) · US

Funding

The three-dimensional spatiotemporal dynamics of human uterine contractions using electromyometrical imaging (EMMI)R01HD104822 · NICHD · WASHINGTON UNIVERSITY · PI CAHILL, ALISON G, SCHWARTZ, ALAN L · 2021 to 2025
$3.2M
Applying Diffusion Basis Spectrum Imaging to Characterize Human Placenta Immuno-response during normal term and preterm pregnanciesR01HD094381 · NICHD · WASHINGTON UNIVERSITY · PI CAHILL, ALISON G, WANG, YONG · 2018 to 2022
$3.1M
NICHD NIH HHS R01 HD094381NICHD NIH HHS R01 HD104822
6 · The paper itself

Abstract

Electromyometrial imaging (EMMI) was recently developed to image the three-dimensional (3D) uterine electrical activation during contractions noninvasively and accurately in sheep. Herein we describe the development and application of a human EMMI system to image and evaluate 3D uterine electrical activation patterns at high spatial and temporal resolution during human term labor. We demonstrate the successful integration of the human EMMI system during subjects' clinical visits to generate noninvasively the uterine surface electrical potential maps, electrograms, and activation sequence through an inverse solution using up to 192 electrodes distributed around the abdomen surface. Quantitative indices, including the uterine activation curve, are developed and defined to characterize uterine surface contraction patterns. We thus show that the human EMMI system can provide detailed 3D images and quantification of uterine contractions as well as novel insights into the role of human uterine maturation during labor progression.

Indexed as

Labor, ObstetricAnimalsElectromyographyFemaleHumansImaging, Three-DimensionalPregnancySheepUterine ContractionUterus

Identifiers

PMID36918533
PMCPMC10015052
OpenAlexW4324151717

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read109
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.