Evidence map›Paper›PMID 36918467›Full record

ArticleVeterinary research communications2023

The dynamics of neutralizing antibodies against SARS-CoV-2 in cats naturally exposed to virus reveals an increase in antibody activity after re-infection.

Sergio Villanueva-Saz, Marivi Martínez, Pablo Rueda, Sara Bolea, María Dolores Pérez, Maite Verde, Andrés Yzuel, Ramón Hurtado-Guerrero, Julián Pardo, Llipsy Santiago and 2 more

Open access · hybridFull text read
In one paragraph

Article in Veterinary research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sergio Villanueva-SazClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain. svs@unizar.es.
Marivi MartínezDepartment of Animal Pathology, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain.
Pablo RuedaClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain.
Sara BoleaClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain.
María Dolores PérezInstituto Agroalimentario de Aragón-IA2 (Universidad de Zaragoza-CITA), Zaragoza, Spain.
Maite VerdeClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain.
Andrés YzuelClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain.
Ramón Hurtado-GuerreroInstitute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza, Edificio I+D, Campus Rio Ebro, Zaragoza, Spain.
Julián PardoAragon Health Research Institute (IIS Aragón), Zaragoza, Spain.
Llipsy SantiagoInstitute of Carbochemistry, CSIC, Madrid, Spain.
Antonio FernándezClinical Immunology Laboratory, Veterinary Faculty, University of Zaragoza, 50013, Zaragoza, Spain.
Maykel AriasAragon Health Research Institute (IIS Aragón), Zaragoza, Spain.
Universidad de Zaragoza · ESInstituto de Carboquímica · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 is the causative agent of Coronavirus Disease 2019 in humans. To date, little is known about the persistence of antibodies against SARS-CoV-2 in animals under natural conditions, in particular susceptible pets such as cat. This study reports the detection and monitoring of the humoral response against SARS-CoV-2 including the detection of immunoglobulins G specific for receptor binding domain of SARS-CoV-2 spike protein by an enzyme-linked immunosorbent assay and neutralizing antibodies by virus neutralization assay. Results showed that these antibodies last longer than 16 months in two naturally apparently healthy infected cats with the absence of clinicopathological findings during the follow-up. Moreover, re-infection is also possible with an important increase in virus neutralization test titers in both animals with no evident systemic signs found during each physical examination and with values of hematologic and biochemical parameters inside the normal reference intervals. Our results confirm a slow but progressive decrease of the kinetics and immunity of neutralizing antibodies in cats after the infection. Furthermore, similar to humans SARS-CoV-2 reinfection can stimulate an increase of the neutralizing antibodies determined by these two serological techniques in domestic cats.

Indexed as

Cat DiseasesCOVID-19AnimalsAntibodies, NeutralizingAntibodies, ViralCatsHumansReinfectionSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2CatELISALong-term persistenceSARS-CoV-2SerologyVNT

Identifiers

PMID36918467
PMCPMC10014409
OpenAlexW4324309235

What OpenQuestion holds

Textfull text, public
LicenceCC BY
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.