Evidence map›Paper›PMID 36918416›Full record

Trial reportEuropean journal of applied physiology2023

Effects of protein-carbohydrate vs. carbohydrate alone supplementation on immune inflammation markers in endurance athletes: a randomized controlled trial.

Diego Moreno-Pérez, Álvaro López-Samanes, Mar Larrosa, Eneko Larumbe-Zabala, Aitor Centeno, Justin Roberts, Fernando Naclerio

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02954367 (Effects of Meat Protein Administration on Body Composition, Strength, Immunological, Microbiota and Haematological Markers in Endurance Athletes), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02954367 naunknown statusnot on this map

Effects of Meat Protein Administration on Body Composition, Strength, Immunological, Microbiota and Haematological Markers in Endurance Athletes

TypeinterventionalSponsorUniversidad Europea de MadridRan2016Enrolled44ConditionsDietary ModificationArmsPROTEIN, CARBOHYDRATE
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. The Immune System as a Biosensor of Health and Athletic Performance.Scandinavian journal of medicine & science in sports · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Diego Moreno-PérezDepartment of Education, Research and Evaluation Methods, Comillas Pontifical University, Madrid, Spain.ORCID http://orcid.org/0000-0002-4737-5534
Álvaro López-SamanesExercise Physiology Group, School of Physiotherapy, Faculty of Health Sciences, Universidad Francisco de Vitoria, Carretera Pozuelo a Majadahonda, Km 1.800, 28223, Madrid, Spain. alvaro.lopez@ufv.es.ORCID http://orcid.org/0000-0003-0721-0150
Mar LarrosaDepartment of Nutrition and Food Science, School of Pharmacy, Complutense University of Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-8863-4686
Eneko Larumbe-ZabalaSchool of Doctorate and Research, European University of Madrid, 28670, Villaviciosa de Odon, Spain.ORCID http://orcid.org/0000-0002-8949-0602
Aitor CentenoDepartment of Education, Research and Evaluation Methods, Comillas Pontifical University, Madrid, Spain.
Justin RobertsCambridge Centre for Sport and Exercise Sciences, School of Psychology and Sports Science, Cambridge, UK.ORCID http://orcid.org/0000-0002-3169-2041
Fernando NaclerioCentre for Exercise Activity and Rehabilitation, Institute for Lifecourse Development, School of Human Science, University of Greenwich, London, UK.ORCID http://orcid.org/0000-0001-7405-4894
Universidad Pontificia Comillas · ESUniversidad Complutense de Madrid · ESUniversidad Europea de Madrid · ESUniversidad Francisco de Vitoria · ESUniversity of Greenwich · GB

Funding

Universidad Europea de Madrid 2016/RM05
6 · The paper itself

Abstract

purposeThe impact of ingesting carbohydrates alone or combined with proteins to support exercise immune adaptation in endurance athletes is scarcely investigated. The present study compares the effect of ingesting a combined protein-carbohydrate supplement vs. a carbohydrate-only supplement post-workout on immune inflammation markers following a 10 week periodized endurance training program in well-trained athletes.

methodsTwenty-five men completed the study after being randomly assigned to one of the following intervention groups: combined protein-carbohydrate (PRO-CHO n = 12, 31 ± 9 years, [Formula: see text]O

resultsPost-intervention, significant increases were observed for CHO group only for the three inflammatory markers: NLR (p = 0.050, d = 0.58), PLR (p = 0.041, d = 0.60), and SII (p = 0.004, d = 0.81) but not for PRO-CHO (p > 0.05).

conclusionIngesting a post-workout protein-carbohydrate combined beverage promoted a more favourable immune status than carbohydrate-only ingestion by attenuating cellular inflammation over a 10 week training period in endurance male athletes.

trial registrationThe study was registered in ClinicalTrials.gov with the following ID: NCT02954367. The study was registered by 3 November 2016.

Indexed as

Dietary CarbohydratesDietary SupplementsAthletesBeveragesBiomarkersHumansMaleNutritional StatusPhysical EnduranceBiomarkersDietary CarbohydratesEndurance performanceExerciseImmunologySports nutrition

Identifiers

PMID36918416
OpenAlexW4324136430

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.