Evidence map›Paper›PMID 36917910›Full record

ReviewCurrent opinion in chemical biology2023

Genetically encoded fluorescent sensors for metals in biology.

Ana P Torres-Ocampo, Amy E Palmer

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ana P Torres-OcampoBioFrontiers Institute, University of Colorado, Boulder, 3415 Colorado Ave, CO, 80303, Boulder, United States.
Amy E PalmerDepartment of Biochemistry, University of Colorado, Boulder, 3415 Colorado Ave, CO, 80303, Boulder, United States; BioFrontiers Institute, University of Colorado, Boulder, 3415 Colorado Ave, CO, 80303, Boulder, United States. Electronic address: amy.palmer@colorado.edu.

Funding

lluminating the biochemistry of zinc and RNA in live cellsR35GM139644 · NIGMS · UNIVERSITY OF COLORADO · PI Amy E Palmer · 2021 to 2026
$3.7M
NIGMS NIH HHS R35 GM139644
6 · The paper itself

Abstract

Metal ions intersect a wide range of biological processes. Some metal ions are essential and hence absolutely required for the growth and health of an organism, others are toxic and there is great interest in understanding mechanisms of toxicity. Genetically encoded fluorescent sensors are powerful tools that enable the visualization, quantification, and tracking of dynamics of metal ions in biological systems. Here, we review recent advances in the development of genetically encoded fluorescent sensors for metal ions. We broadly focus on 5 classes of sensors: single fluorescent protein, FRET-based, chemigenetic, DNAzymes, and RNA-based. We highlight recent developments in the past few years and where these developments stand concerning the rest of the field.

Indexed as

Biosensing TechniquesDNA, CatalyticBiologyFluorescent DyesIonsMetalsDNA, CatalyticFluorescent DyesIonsMetalsFluorescentGenetically encodedMetal ionsSensors

Identifiers

PMID36917910
PMCPMC10573084

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.