Evidence map›Paper›PMID 36917773›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2023

Surfactant Proteins SP-B and SP-C in Pulmonary Surfactant Monolayers: Physical Properties Controlled by Specific Protein-Lipid Interactions.

Juho Liekkinen, Agnieszka Olżyńska, Lukasz Cwiklik, Jorge Bernardino de la Serna, Ilpo Vattulainen, Matti Javanainen

Abstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. The Immune Modulatory Role of Surfactants inJournal of inflammation research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juho LiekkinenDepartment of Physics, University of Helsinki, FI-00560 Helsinki, Finland.ORCID 0000-0002-6612-1361
Agnieszka OlżyńskaJ. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, CZ-18223 Prague, Czech Republic.ORCID 0000-0001-6533-5280
Lukasz CwiklikJ. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, CZ-18223 Prague, Czech Republic.ORCID 0000-0002-2083-8738
Jorge Bernardino de la SernaNational Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, London SW7 2AZ, U.K.ORCID 0000-0002-1396-3338
Ilpo VattulainenDepartment of Physics, University of Helsinki, FI-00560 Helsinki, Finland.ORCID 0000-0001-7408-3214
Matti JavanainenInstitute of Biotechnology, University of Helsinki, FI-00790 Helsinki, Finland.ORCID 0000-0003-4858-364X

Funding

Biotechnology and Biological Sciences Research Council BB/V019791/1
6 · The paper itself

Abstract

The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-active lipids and proteins that enables efficient gas exchange between inhaled air and the circulation. Despite decades of advancements in the study of the pulmonary surfactant, the molecular scale behavior of the surfactant and the inherent role of the number of different lipids and proteins in surfactant behavior are not fully understood. The most important proteins in this complex system are the surfactant proteins SP-B and SP-C. Given this, in this work we performed nonequilibrium all-atom molecular dynamics simulations to study the interplay of SP-B and SP-C with multicomponent lipid monolayers mimicking the pulmonary surfactant in composition. The simulations were complemented by

Indexed as

Pulmonary SurfactantsBiophysical PhenomenaPhospholipidsProteinsPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CSurface-Active AgentsSurface PropertiesPhospholipidsProteinsPulmonary Surfactant-Associated Protein BPulmonary Surfactant-Associated Protein CPulmonary SurfactantsSurface-Active Agents

Identifiers

PMID36917773
PMCPMC10061932

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.