ReviewAmerican journal of respiratory and critical care medicine2023
Diaphragm Neurostimulation Assisted Ventilation in Critically Ill Patients.
Review in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Respiratory muscle dysfunction in mechanical ventilation: a systematic review and meta-analysis of biological mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Pooled it
- Diaphragm neurostimulation mitigates the adverse cardiopulmonary effects of positive pressure ventilation.Critical care (London, England) · 2026Trial
- The emerging role of diaphragm neurostimulation in ARDS.Intensive care medicine · 2026Article
- From physiological innovation to clinical precision: defining the right target for diaphragm neurostimulation.Journal of thoracic disease · 2026Article
- Early career member highlights from the ERS Respiratory Failure and Mechanical Ventilation Conference 2026.Breathe (Sheffield, England) · 2026Article
- Targeting the diaphragm during weaning from mechanical ventilation.Journal of thoracic disease · 2026Article
- Effects of Phrenic Nerve Stimulation in Mechanically Ventilated Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Application of bedside ultrasound assessment of diaphragmatic function in preparing tracheostomised patients for ventilator liberation and decannulation: a narrative review.Journal of thoracic disease · 2026Review
- The Effect of Body Position on Responses to Rapid Bilateral Anterolateral Magnetic Phrenic Nerve Stimulation in Healthy Humans (PosiStim).Respiration; international review of thoracic diseases · 2026Article
- A preclinical rat model for bilateral phrenic nerve stimulation during mechanical ventilation.Animal models and experimental medicine · 2026Article
- Feasibility of transcranial magnetic stimulation adjuvant therapy for chronic respiratory diseases: a narrative review.Frontiers in rehabilitation sciences · 2026Review
- The first case of diaphragm pacing system implantation in a patient with high cervical spinal cord injury in taiwan: a case report and literature review.Journal of cardiothoracic surgery · 2025Review
- Diaphragm dysfunction from phrenic nerve injuries during LVAD or heart transplant: Positive role of diaphragm pacing.JHLT open · 2025Article
- Advancements in imaging techniques for monitoring the respiratory muscles.Critical care (London, England) · 2025Review
- Within- and between-day test-retest reliability of responses to rapid bilateral anterolateral magnetic phrenic nerve stimulation in healthy humans (ReStim).Frontiers in physiology · 2025Article
- Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Breath-by-breath comparison of a novel percutaneous phrenic nerve stimulation approach with mechanical ventilation in juvenile pigs: a pilot study.Scientific reports · 2024Article
- Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury.Intensive care medicine experimental · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 6 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diaphragm neurostimulation consists of placing electrodes directly on or in proximity to the phrenic nerve(s) to elicit diaphragmatic contractions. Since its initial description in the 18th century, indications have shifted from cardiopulmonary resuscitation to long-term ventilatory support. Recently, the technical development of devices for temporary diaphragm neurostimulation has opened up the possibility of a new era for the management of mechanically ventilated patients. Combining positive pressure ventilation with diaphragm neurostimulation offers a potentially promising new approach to the delivery of mechanical ventilation which may benefit multiple organ systems. Maintaining diaphragm contractions during ventilation may attenuate diaphragm atrophy and accelerate weaning from mechanical ventilation. Preventing atelectasis and preserving lung volume can reduce lung stress and strain and improve homogeneity of ventilation, potentially mitigating ventilator-induced lung injury. Furthermore, restoring the thoracoabdominal pressure gradient generated by diaphragm contractions may attenuate the drop in cardiac output induced by positive pressure ventilation. Experimental evidence suggests diaphragm neurostimulation may prevent neuroinflammation associated with mechanical ventilation. This review describes the historical development and evolving approaches to diaphragm neurostimulation during mechanical ventilation and surveys the potential mechanisms of benefit. The review proposes a research agenda and offers perspectives for the future of diaphragm neurostimulation assisted mechanical ventilation for critically ill patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.