Evidence map›Paper›PMID 36917716›Full record

ArticleBrain and behavior2023

Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.

Carlos Estevez-Fraga, Michael S Elmalem, Marina Papoutsi, Alexandra Durr, Elin M Rees, Nicola Z Hobbs, Raymund A C Roos, Bernhard Landwehrmeyer, Blair R Leavitt, Douglas R Langbehn and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Fluid and Imaging Biomarkers in Huntington's Disease.Current neurology and neuroscience reports · 2026
    Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 6 countries.

Carlos Estevez-FragaHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0001-6855-1093
Michael S ElmalemHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Marina PapoutsiHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0003-0971-8361
Alexandra DurrSorbonne Université, Paris Brain Institute (ICM), AP-HP, Inserm, CNRS, Pitié-Salpêtrière University Hospital, Paris, France.ORCID 0000-0002-8921-7104
Elin M ReesIxico, London, UK.
Nicola Z HobbsHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Raymund A C RoosDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Bernhard LandwehrmeyerDepartment of Neurology, University of Ulm, Ulm, Germany.ORCID 0000-0003-3375-790X
Blair R LeavittCentre for Huntington's Disease at UBC Hospital, Department of Medical Genetics and Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-4532-766X
Douglas R LangbehnDepartment of Psychiatry, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0002-7803-4679
Rachael I ScahillHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-1832-106X
Geraint ReesWellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-9623-7007
Sarah J TabriziHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0003-2716-2045
Sarah GregoryHuntington's Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Huntington's Disease Association · GBCentre National de la Recherche Scientifique · FRIxico (United Kingdom) · GBLeiden University Medical Center · NLUniversität Ulm · DEUniversity of British Columbia Hospital · CAUniversity of Iowa · USWellcome Centre for Human Neuroimaging · GB

Funding

Medical Research CouncilWellcome TrustWellcome Trust 200181/Z/15/Z
6 · The paper itself

Abstract

backgroundWhole-brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecourse of Huntington's disease (HD).

methodsWe examined changes in WM microstructure from premanifest to early manifest disease, using data from two cohorts with different disease burden. The TrackOn-HD study included 67 controls, 67 premanifest, and 10 early manifest HD (baseline and 24-month data); the PADDINGTON study included 33 controls and 49 early manifest HD (baseline and 15-month data). Longitudinal changes in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, and radial diffusivity from baseline to last study visit were investigated for each cohort using tract-based spatial statistics. An optimized pipeline was employed to generate participant-specific templates to which diffusion tensor imaging maps were registered and change maps were calculated. We examined longitudinal differences between HD expansion-carriers and controls, and correlations with clinical scores, including the composite UHDRS (cUHDRS).

resultsHD expansion-carriers from TrackOn-HD, with lower disease burden, showed a significant longitudinal decline in FA in the left superior longitudinal fasciculus and an increase in MD across subcortical WM tracts compared to controls, while in manifest HD participants from PADDINGTON, there were significant widespread longitudinal increases in diffusivity compared to controls. Baseline scores in clinical scales including the cUHDRS predicted WM microstructural change in HD expansion-carriers.

conclusionThe present study showed significant longitudinal changes in WM microstructure across the HD timecourse. Changes were evident in larger WM areas and across more metrics as the disease advanced, suggesting a progressive alteration of WM microstructure with disease evolution.

Indexed as

Huntington DiseaseWhite MatterBrainDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingHumansdiffusion tensor imagingHuntington's diseaselongitudinalpresymptomaticsymptomatic

Identifiers

PMID36917716
PMCPMC10097137
OpenAlexW4324132583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.